In Reply We found in a double-blind, randomized, placebo-controlled trial that high-dose vitamin D supplementation during pregnancy was associated with reduced risk of recurrent wheeze¹ and enamel defects in offspring.² Deng and Niu suggest that this finding was flawed by residual confounding. However, the design mitigates confounding. This is demonstrated in our study showing equal distribution of lifestyle-related factors between groups. Therefore, our results cannot be biased from residual confounding.

中文翻译：

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怀孕期间补充维生素D和后代中的釉质缺损。

在答复中，我们在一项双盲，随机，安慰剂对照试验中发现，怀孕期间大剂量补充维生素D与降低复发性喘息¹和后代牙釉质缺陷的风险有关。²邓和牛认为该发现存在残留混杂的缺陷。但是，该设计减轻了混淆。这在我们的研究中得到了证明，表明各组之间与生活习惯相关的因素平均分配。因此，我们的结果不能因残留混杂而产生偏差。