Nørrisgaard et al¹ reported important findings from a randomized clinical trial that the odds of enamel defects in offspring were lowered by approximately 50% with high-dose vitamin D supplement during pregnancy than with the low dose during a 6-year follow-up. Enamel defects constitute a global problem reaching epidemic proportions,² and identification and management of potential risk factors remains a major public health priority. The study by Nørrisgaard et al¹ sheds some light on this problem, underscoring the importance of administering high-dose vitamin D to pregnant women. However, we are concerned about the residual confounding that might restrict explanation and extrapolation of these findings to the general population.

Nørrisgaard等人¹报道了一项来自一项随机临床试验的重要发现，即在妊娠6年的随访中，高剂量补充维生素D与低剂量相比，后代牙釉质缺损的几率降低了约50％。牙釉质缺陷是一个全球性问题，已经达到流行病的程度²，对潜在危险因素的识别和管理仍然是公共卫生的主要重点。Nørrisgaard等人的研究[ ^1]阐明了这个问题，强调了向孕妇服用大剂量维生素D的重要性。但是，我们关注的是可能会限制将这些发现的解释和外推到普通人群中的残余混淆。