The gut microbiota and its interactions with cardiovascular disease.,Microbial Biotechnology

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The gut microbiota and its interactions with cardiovascular disease.
Microbial Biotechnology ( IF 4.8 ) Pub Date : 2020-01-26 , DOI: 10.1111/1751-7915.13524
Hui Xu _{1,

2} , Xiang Wang ₁ , Wenke Feng _{3,

4} , Qi Liu _{3,

4,

5} , Shanshan Zhou ₁ , Quan Liu ₁ , Lu Cai _{2,

3}

Affiliation

The intestine is colonized by a considerable community of microorganisms that cohabits within the host and plays a critical role in maintaining host homeostasis. Recently, accumulating evidence has revealed that the gut microbial ecology plays a pivotal role in the occurrence and development of cardiovascular disease (CVD). Moreover, the effects of imbalances in microbe–host interactions on homeostasis can lead to the progression of CVD. Alterations in the composition of gut flora and disruptions in gut microbial metabolism are implicated in the pathogenesis of CVD. Furthermore, the gut microbiota functions like an endocrine organ that produces bioactive metabolites, including trimethylamine/trimethylamine N‐oxide, short‐chain fatty acids and bile acids, which are also involved in host health and disease via numerous pathways. Thus, the gut microbiota and its metabolic pathways have attracted growing attention as a therapeutic target for CVD treatment. The fundamental purpose of this review was to summarize recent studies that have illustrated the complex interactions between the gut microbiota, their metabolites and the development of common CVD, as well as the effects of gut dysbiosis on CVD risk factors. Moreover, we systematically discuss the normal physiology of gut microbiota and potential therapeutic strategies targeting gut microbiota to prevent and treat CVD.

中文翻译：

肠道微生物群及其与心血管疾病的相互作用。

肠道内栖息着相当多的微生物群落，这些微生物在宿主体内共居，在维持宿主体内平衡方面发挥着关键作用。近年来，越来越多的证据表明肠道微生物生态在心血管疾病（CVD）的发生和发展中发挥着关键作用。此外，微生物与宿主相互作用的不平衡对体内平衡的影响可能导致心血管疾病的进展。肠道菌群组成的改变和肠道微生物代谢的破坏与CVD的发病机制有关。此外，肠道微生物群的功能类似于内分泌器官，产生生物活性代谢物，包括三甲胺/三甲胺N氧化物、短链脂肪酸和胆汁酸，这些代谢物也通过多种途径参与宿主健康和疾病。因此，肠道微生物群及其代谢途径作为CVD治疗的治疗靶点引起了越来越多的关注。本综述的根本目的是总结最近的研究，这些研究阐明了肠道微生物群、其代谢物与常见 CVD 发展之间复杂的相互作用，以及肠道菌群失调对 CVD 危险因素的影响。此外，我们系统地讨论了肠道微生物群的正常生理学以及针对肠道微生物群预防和治疗心血管疾病的潜在治疗策略。

更新日期：2020-01-26

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