Isatin dimers and their biological activities,Archiv der Pharmazie

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Isatin dimers and their biological activities
Archiv der Pharmazie ( IF 4.3 ) Pub Date : 2020-01-27 , DOI: 10.1002/ardp.201900299
Ya-Zhou Zhang ₁ , Hong-Zhi Du ₁ , Hai-Lin Liu ₁ , Qian-Song He ₁ , Zhi Xu ₁

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Dimerization is a promising strategy to develop novel drug candidates that could extend the biological spectrum, enhance the activity, overcome drug resistance, as well as improve pharmacological, pharmacokinetic, and physicochemical profiles. Isatin dimers possess a broad spectrum of biological properties and the isatin dimer indirubin has already been used in the clinic, revealing the potential of isatin dimers as putative drugs. This review covers the recent advances of isatin dimers as pharmacologically significant scaffolds and the structure–activity relationship to set up the direction for the design and development of isatin dimers with higher efficiency and lower toxicity.

中文翻译：

靛红二聚体及其生物活性

二聚化是开发可扩展生物谱、增强活性、克服耐药性以及改善药理学、药代动力学和理化特征的新型候选药物的有前景的策略。靛红二聚体具有广泛的生物学特性，并且靛红二聚体已经用于临床，揭示了靛红二聚体作为推定药物的潜力。这篇综述涵盖了靛红二聚体作为药理学重要支架的最新进展以及构效关系，为设计和开发具有更高效率和更低毒性的靛红二聚体奠定了方向。

更新日期：2020-01-27

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