BACKGROUND Hepatitis C virus (HCV) infection is the most prevalent blood-borne infection and causes more deaths than any other infectious disease in the US. Incident HCV infection in the US increased nearly 300 % between 2010 and 2015, Community viral load (CVL) measures have been developed for HIV to measure both transmission risk and treatment engagement in programs or areas. OBJECTIVE This paper presents a systematic review exploring the published literature on CVL constructs applied to HCV epidemiology and proposes novel CVL measures for HCV. STUDY DESIGN AND SETTING A systematic review was conducted of electronic databases; the search sought to identify published literature on HCV which discussed or applied CVL measures to HCV epidemiology. Novel CVL measures were constructed to apply to HCV. RESULTS No reports examining quantitative measures of HCV CVL were identified. Using the HIV CVL literature and the specific characteristics of HCV epidemiology, five HCV CVL measures are proposed. Narrower measures focusing on those engaged-in-care may be useful for program evaluation and broader measures including undiagnosed people may be useful for surveillance of HCV transmission potential. CONCLUSION Despite their potential value, CVL constructs have not yet formally been developed and applied to HCV epidemiology. The CVL measures proposed here could serve as valuable HCV program and surveillance measures. There is a need for informative surveillance measures to enhance policy and public health responses to achieve HCV control. Further study of these proposed HCV CVL measures to HCV epidemiology is warranted.

中文翻译：

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社区病毒载量和丙型肝炎病毒感染：帮助公共卫生治疗工作和项目评估的社区病毒载量测量。


背景技术丙型肝炎病毒（HCV）感染是最常见的血液传播感染，在美国造成的死亡人数比任何其他传染病都要多。 2010 年至 2015 年间，美国 HCV 感染事件增加了近 300%，针对 HIV 制定了社区病毒载量 (CVL) 措施，以衡量项目或地区的传播风险和治疗参与度。目的 本文对已发表的 CVL 结构应用于 HCV 流行病学的文献进行了系统综述，并提出了针对 HCV 的新 CVL 测量方法。研究设计和设置 对电子数据库进行了系统审查；该检索旨在找出有关 HCV 的已发表文献，这些文献讨论了 CVL 措施或将 CVL 措施应用于 HCV 流行病学。构建了适用于 HCV 的新型 CVL 测量方法。结果 未发现检查 HCV CVL 定量测量的报告。利用HIV CVL文献和HCV流行病学的具体特征，提出了五种HCV CVL措施。针对参与护理人员的更窄范围的措施可能有助于项目评估，而包括未确诊人群在内的更广泛的措施可能有助于监测丙型肝炎病毒的传播潜力。结论 尽管 CVL 结构具有潜在价值，但尚未正式开发并应用于 HCV 流行病学。这里提出的 CVL 措施可以作为有价值的 HCV 计划和监测措施。需要采取信息丰富的监测措施来加强政策和公共卫生应对措施，以实现丙肝病毒控制。有必要对这些拟议的 HCV CVL 措施进行 HCV 流行病学进一步研究。