With the development of nanotechnology, self-assembled chitosan/phospholipid nanoparticles (SACPNs) show great promise in a broad range of applications, including therapy, diagnosis, in suit imaging and on-demand drug delivery. Here, a brief review of the SACPNs is presented, and its critical underlying formation mechanisms are interpreted with an emphasis on the intrinsic physicochemical properties. The state-of-art preparation methods of SACPNs are summarized, with particular descriptions about the classic solvent injection method. Then SACPNs microstructures are characterized, revealing the unique spherical core-shell structure and the drug release mechanisms. Afterwards, a comprehensive and in-depth depiction of their emerging applications, with special attention to drug delivery areas, are categorized and reviewed. Finally, conclusions and outlooks on further advancing the SACPNs toward a more powerful and versatile platform for investigations covering from fundamental understanding to developing multi-functional drug delivery systems are discussed.

中文翻译：

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自组装壳聚糖/磷脂纳米粒子：从基础知识到高级药物输送的准备。


随着纳米技术的发展，自组装壳聚糖/磷脂纳米粒子（SACPNs）在治疗、诊断、套装成像和按需药物输送等广泛应用中显示出巨大的前景。在这里，对 SACPN 进行了简要回顾，并解释了其关键的潜在形成机制，重点是内在的物理化学性质。总结了 SACPNs 的最新制备方法，并特别描述了经典的溶剂注射方法。然后对 SACPNs 的微观结构进行了表征，揭示了独特的球形核壳结构和药物释放机制。随后，对它们的新兴应用进行了全面、深入的描述，特别关注药物输送领域，并进行了分类和回顾。最后，讨论了进一步推进 SACPN 成为更强大、更通用的研究平台的结论和展望，涵盖从基本理解到开发多功能药物输送系统。