A series of core-shell mesoporous silica nanoparticles ([email protected]) were successfully prepared with reducing response environmental stimuli TEOS-BTES as a shell and mesoporous silica nanoparticles (MSN) as a core. The results demonstrated that both MSN and [email protected] possessed spherical mesoporous structure and good porosity. Moreover, the size of particles and thickness of shell can be regulated by BTES amount. Besides, Indomethacin (IMC) could be loaded into the silica carriers in amorphous state, and the IMC loading amount was positively correlated with the pore volume. The release profile illustrated that the TEOS-BTES shell coating on the surface of MSN could act as reducing activatable trigger to achieve control release, while MSN provided enough space to encapsulate IMC with high loading. It was also found that MSN and [email protected] could be degraded in vitro. Furthermore, both IMC-MSN and [email protected] could reduce the gastric mucosa irritation and improve the bioavailability of IMC, and IMC-loaded MSN had a higher bioavailability than IMC-loaded [email protected]

以减少响应性环境刺激物TEOS-BTES为壳，以介孔二氧化硅纳米颗粒（MSN）为核心，成功制备了一系列核-壳介孔二氧化硅纳米颗粒（[受电子邮件保护]）。结果表明，MSN和[受电子邮件保护]均具有球形的介孔结构和良好的孔隙率。而且，颗粒的大小和壳的厚度可以通过BTES的量来调节。此外，吲哚美辛（IMC）可以以非晶态负载在二氧化硅载体中，且IMC的负载量与孔体积呈正相关。释放曲线表明，MSN表面的TEOS-BTES外壳涂层可以起到减少可激活触发器的作用，从而实现控制释放，而MSN提供了足够的空间来封装高负载的IMC。还发现MSN和[受电子邮件保护]可以在体外降解。此外，IMC-MSN和[电子邮件保护]都可以减少胃粘膜刺激并改善IMC的生物利用度，与IMC负载[电子邮件保护]相比，IMC负载的MSN具有更高的生物利用度。