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A heterogeneous gold(I)-catalyzed regioselective hydration of propargyl acetates toward α-acyloxy methyl ketones
Journal of Organometallic Chemistry ( IF 2.1 ) Pub Date : 2020-01-26 , DOI: 10.1016/j.jorganchem.2020.121136
Yingying Du , Fang Yao , Rongli Zhang , Mingzhong Cai

A heterogeneous gold(I)-catalyzed regioselective hydration of propargyl acetates has been developed that proceeds smoothly in 1,4-dioxane at room temperature in the presence of 1 mol% diphenylphosphine-modified MCM-41-anchored gold(I) complex [Ph2P-MCM-41-AuSbF6] as catalyst and provides an efficient and practical approach for the synthesis of a variety of α-acyloxy methyl ketones with high atom economy, good to excellent yield, and high functional group tolerance. This new immobilized gold(I) catalyst can readily be obtained by a simple preparative procedure from commercially available reagents, and recovered via a filtration process and reused at least seven times without apparent loss of activity.



中文翻译:

炔丙基乙酸酯向α-酰氧基甲基酮的异质金(I)催化区域选择性水合

已经开发出了炔丙基乙酸酯的多相金(I)催化区域选择性水合,可在室温下在1 mol%二苯膦改性的MCM-41固定的金(I)络合物存在下,在1,4-二恶烷中平稳进行。2 P-MCM-41-AuSbF 6 ]作为催化剂,为合成具有高原子经济性,良好至优异收率和高官能团耐受性的各种α-酰氧基甲基酮提供了一种高效实用的方法。这种新的固定化金(I)催化剂可以通过简单的制备程序轻松地从市售试剂中获得,并通过过滤过程进行回收,并至少重复使用7次,而活性没有明显降低。

更新日期:2020-01-26
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