Cardiovascular disease is the leading cause of the death for both men and women. Although baseline heart physiology and the response to disease are known to differ by sex, little is known about sex differences in baseline molecular signaling, especially with regard to redox biology. In this review, we describe current research on sex differences in cardiac redox biology with a focus on the regulation of nitric oxide and aldehyde signaling. Furthermore, we argue for a new perspective on cardiovascular sex differences research, one that focuses on baseline redox biology without the elimination or disruption of sex hormones.

中文翻译：

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性别差异的新兴观点：心脏中相交的S-亚硝基硫醇和醛信号。

心血管疾病是男女死亡的主要原因。尽管已知基线心脏生理和对疾病的反应因性别而异，但对基线分子信号传导中的性别差异知之甚少，尤其是在氧化还原生物学方面。在这篇综述中，我们描述了当前心脏氧化还原生物学中性别差异的研究，重点是对一氧化氮和醛信号的调节。此外，我们提出了关于心血管性别差异研究的新观点，该观点侧重于基线氧化还原生物学而不消除或破坏性激素。