The Mood Disorder Questionnaire (MDQ) is an established screening tool for bipolar spectrum disorders (BSD), but has not been validated in diverse populations and the best scoring method remains uncertain. This study assessed diagnostic validity of the MDQ among Anabaptists, an underserved population frequently involved in genetic research. 161 participants completed the MDQ and were diagnosed by a best-estimate final diagnosis (BEFD). Diagnostic agreements between alternate MDQ scoring methods and the BEFD were quantified using Cohen's Kappa (κ), sensitivity (α), and specificity (β). Scoring criteria evaluated included >7 simultaneous symptoms and at least moderate impairment, >7 simultaneous symptoms, with at least mild impairment, >7 symptoms only, with no further requirement, and three novel scoring methods that require >5 symptoms or fewer. Diagnostic agreement varied. The original method proved most specific but had the lowest κ and sensitivity. κ increased with more liberal scoring criteria, reaching a maximum under the lower-threshold symptom methods, with little loss of specificity in the 5-symptom method. Decreasing the symptom threshold below 5 conferred little or no benefit. These results support the diagnostic validity of the MDQ among this Anabaptist sample and suggest that a 5-symptom scoring method may increase diagnostic sensitivity in populations at high risk for bipolar disorder.

中文翻译：

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情绪障碍问卷（MDQ）作为针对洗礼人群中双相谱障碍的筛查工具的有效性。

情绪障碍问卷（MDQ）是一种用于双相谱障碍（BSD）的成熟筛查工具，但尚未在各种人群中得到验证，最佳评分方法仍然不确定。这项研究评估了惯常主义者中MDQ的诊断有效性，惯常主义者是经常参与基因研究的服务不足的人群。161名参与者完成了MDQ，并通过最佳估计最终诊断（BEFD）被诊断。使用Cohen的Kappa（κ），敏感性（α）和特异性（β）来量化MDQ评分方法与BEFD之间的诊断一致性。评估的评分标准包括> 7个同时出现的症状和至少中度障碍，> 7个同时出现的症状，至少有轻度障碍，仅> 7个症状，没有进一步的要求以及三种新颖的评分方法要求> 5个症状或更少。诊断协议各不相同。原始方法证明是最特异性的，但κ和灵敏度最低。κ随着评分标准的提高而增加，在较低阈值的症状方法中达到最大值，而在5-症状方法中特异性损失很小。将症状阈值降低到5以下几乎没有好处。这些结果支持该再洗礼样本中MDQ的诊断有效性，并提示5症状评分方法可能会增加双相情感障碍高风险人群的诊断敏感性。在5症状法中几乎没有特异性丧失。将症状阈值降低到5以下几乎没有好处。这些结果支持该再洗礼样本中MDQ的诊断有效性，并表明5症状评分方法可能会增加双相情感障碍高风险人群的诊断敏感性。在5症状法中几乎没有特异性丧失。将症状阈值降低到5以下几乎没有好处。这些结果支持该再洗礼样本中MDQ的诊断有效性，并表明5症状评分方法可能会增加双相情感障碍高风险人群的诊断敏感性。