Epigallocatechin gallate (EGCG), an active polyphenol in green tea, exhibits various physiological effects, including activation of low‐density lipoprotein receptors (LDLR). The previous studies have suggested that EGCG activates LDLR via extracellular signal‐regulated kinase (ERK) pathway in HepG2 cells. However, the detailed molecular mechanism remains unclear. Recently, 67 kDa laminin receptor (67LR) is identified as a receptor for EGCG. Therefore, this study aims to determine whether 67LR is involved in the mechanism of LDLR activation by EGCG.

中文翻译：

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表没食子儿茶素没食子酸酯通过HepG2细胞中的67 kDa层粘连蛋白受体独立途径诱导LDL受体上调。

没食子儿茶素没食子酸酯（EGCG）是绿茶中的一种活性多酚，具有多种生理效应，包括激活低密度脂蛋白受体（LDLR）。先前的研究表明，EGCG通过HepG2细胞中的细胞外信号调节激酶（ERK）途径激活LDLR。但是，详细的分子机制仍不清楚。最近，67 kDa层粘连蛋白受体（67LR）被确定为EGCG的受体。因此，本研究旨在确定67LR是否参与EGCG激活LDLR的机制。