The SWI/SNF (mating type SWItch/Sucrose NonFermentable) chromatin remodeling complexes interact with histones and transcription factors to modulate chromatin structure and control gene expression. These evolutionarily conserved multisubunit protein complexes are involved in regulating many biological functions, such as differentiation and cell proliferation. Genomic studies have revealed frequent mutations of genes encoding multiple subunits of the SWI/SNF complexes in a wide spectrum of cancer types, including gynecologic cancers. These SWI/SNF mutations occur at different stages of tumor development and are restricted to unique histologic types of gynecologic cancers. Thus, SWI/SNF mutations have to function in the appropriate tissue and cell context to promote gynecologic cancer initiation and progression. In this review, we summarize the current knowledge of SWI/SNF mutations in the development of gynecologic cancers to provide insights into both molecular pathogenesis and possible treatment implications for these diseases.

中文翻译：

---

妇科癌症中的SWI / SNF复合物突变：分子机制和模型。

SWI / SNF（交配型SWItch /蔗糖不可发酵）染色质重塑复合物与组蛋白和转录因子相互作用，以调节染色质结构并控制基因表达。这些进化上保守的多亚基蛋白复合物参与调节许多生物学功能，例如分化和细胞增殖。基因组研究表明，在包括妇科癌症在内的多种癌症类型中，编码SWI / SNF复合体多个亚基的基因经常发生突变。这些SWI / SNF突变发生在肿瘤发展的不同阶段，并且仅限于妇科癌症的独特组织学类型。因此，SWI / SNF突变必须在适当的组织和细胞环境中起作用，以促进妇科癌症的发生和发展。在这篇评论中