Acute traumatic nail injury treatment repair procedures are commonly conducted in emergency departments and primary care offices. Current repair methods use nail splints that are inserted within the nail root to prevent the fusion of the proximal nail fold and the matrix tissue. Splints provide a protective barrier overlying the nail bed soft tissue during recovery periods, but uncertain prognoses (i.e., aesthetic and functional disadvantages) reveal a need for improved nail repair techniques. Nail splints are not specifically designed for nail organ restoration via biological mechanisms, thus, a clinical application that utilizes regenerative engineering techniques can prove useful in improving the nail injury prognoses. Using the coaxial electrospinning method, hybrid poly(lactide‐co‐glycolide) (PLGA) (85:15) and gelatin fibrous scaffolds (Hybrid_1: PLGA shell, gelatin core and Hybrid₂: gelatin shell, PLGA core) with average fiber diameters of 540 ± 118 and 2,215 ± 1,135 nm, respectively, were produced and successful encapsulation of core fibers was observed. Furthermore, nail stem cells expressing stem cell characteristic markers CD90, CD29, and Lgr6 showed preferred attachment to Hybrid₂ scaffolds after 24 hr. Overall, an in vitro regenerative engineered nail matrix may aid to improve the cosmetic appearance and function of injured nail organs post‐traumatic injury.

中文翻译：

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指甲基质再生工程：聚（丙交酯-共-乙交酯）/明胶纤维基质的体外评估。

急性外伤性指甲损伤治疗修复程序通常在急诊科和初级保健办公室进行。目前的修复方法使用插入指甲根部的指甲夹板来防止近端甲皱襞和基质组织的融合。夹板在恢复期间提供了覆盖甲床软组织的保护屏障，但不确定的预后（即美学和功能缺陷）表明需要改进指甲修复技术。指甲夹板不是专门为通过生物机制修复指甲器官而设计的，因此，利用再生工程技术的临床应用可以证明有助于改善指甲损伤的预后。使用同轴静电纺丝法，混合的聚（丙交酯-共-乙交酯) (PLGA) (85:15) 和明胶纤维支架（Hybrid _1： PLGA 壳，明胶核和 Hybrid ₂：明胶壳，PLGA 核）平均纤维直径分别为 540 ± 118 和 2,215 ± 1,135 nm，生产并观察到芯纤维的成功封装。此外，表达干细胞特征标记 CD90、CD29 和 Lgr6 的指甲干细胞在 24 小时后显示出与 Hybrid ₂支架的优先连接。总体而言，体外再生工程指甲基质可能有助于改善创伤后指甲器官的外观和功能。