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Combined Magnetic Resonance Imaging and Photodynamic Therapy Using Polyfunctionalised Nanoparticles Bearing Robust Gadolinium Surface Units.
Chemistry - A European Journal ( IF 3.9 ) Pub Date : 2020-01-25 , DOI: 10.1002/chem.201904757
Nicolas G Chabloz 1 , Hannah L Perry 1, 2 , Il-Chul Yoon 1 , Andrew J Coulson 1 , Andrew J P White 1 , Graeme J Stasiuk 3 , René M Botnar 2 , James D E T Wilton-Ely 1, 4
Affiliation  

A robust dithiocarbamate tether allows novel gadolinium units based on DOTAGA (q = 1) to be attached to the surface of gold nanoparticles (2.6 - 4.1 nm diameter) along with functional units offering biocompatibility, targeting and photodynamic therapy. A dramatic increase in relaxivity (r1) per Gd unit from 5.01 mM-1 s-1 in unbound form to 31.68 mM-1 s-1 (10 MHz, 37 °C) is observed when immobilised on the surface due to restricted rotation and enhanced rigidity of the Gd complex on the nanoparticle surface. The single-step synthetic route provides a straightforward and versatile way of preparing multifunctional gold nanoparticles, including examples with conjugated zinc-tetraphenylporphyrin photosensitizers. The lack of toxicity of these materials (MTT assays) is transformed on irradiation of HeLa cells for 30 minutes (PDT), leading to 75% cell death. In addition to passive targeting, the inclusion of units capable of actively targeting overexpressed folate receptors illustrates the potential of these assemblies as targeted theranostic agents.

中文翻译:

使用带有坚固Imaging表面单元的多官能化纳米粒子,将磁共振成像和光动力疗法相结合。

强大的二硫代氨基甲酸酯系链可将基于DOTAGA(q = 1)的新型g单元与提供生物相容性,靶向和光动力疗法的功能单元连接到金纳米颗粒(直径2.6-4.1 nm)的表面。当由于旋转和旋转受限制而固定在表面上时,观察到每Gd单位的弛豫度(r1)从无结合形式的5.01 mM-1 s-1急剧增加到31.68 mM-1 s-1(10 MHz,37°C) Gd配合物在纳米颗粒表面的刚性增强。一步合成路线提供了制备多功能金纳米颗粒的直接且通用的方法,包括带有共轭锌四苯基卟啉光敏剂的例子。这些材料缺乏毒性(MTT分析)是在HeLa细胞照射30分钟(PDT)后转变的,导致75%的细胞死亡。除了被动靶向外,能够主动靶向过表达的叶酸受体的单元的加入还说明了这些组件作为靶向治疗药物的潜力。
更新日期:2020-03-19
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