Patch plays an important role in clinical medicine for its broad applications in tissue repair and regeneration. Here, inspired by the diverse adhesion, anti-adhesion, and responsive structural color phenomena in biological interfaces, we present a hybrid hydrogel film with an adhesive polydopamine (PDA) layer and an anti-adhesive poly(ethylene glycol) diacrylate (PEGDA) layer in an inverse opal scaffold. It was demonstrated that the resultant hydrogel film could serve as a functional tissue patch with an excellent adhesion property on one surface for repairing injured tissues and an anti-adhesion property on the other surface for preventing adverse adhesion. Besides, because of the responsive structural color, the patch was imparted with self-reporting mechanical capability, which could provide a real-time color-sensing feedback to monitor the heartbeat activity. Moreover, the catechol groups on PDA imparted the patch with high tissue adhesiveness and self-healing capability in vivo. These features give the bioinspired patch high potential in biomedical applications.

中文翻译：

---

具有各向异性表面粘附力的仿生结构色块。


补片因其在组织修复和再生方面的广泛应用而在临床医学中发挥着重要作用。在这里，受到生物界面中各种粘附、抗粘附和响应性结构颜色现象的启发，我们提出了一种具有粘附性聚多巴胺（PDA）层和抗粘附性聚（乙二醇）二丙烯酸酯（PEGDA）层的混合水凝胶薄膜在反蛋白石支架中。结果表明，所得水凝胶膜可用作功能性组织补片，其一个表面具有优异的粘附性能，用于修复受损组织，而另一表面具有抗粘附性能，可防止不良粘附。此外，由于具有响应性的结构颜色，该贴片被赋予了自我报告的机械能力，可以提供实时的颜色传感反馈来监测心跳活动。此外，PDA上的儿茶酚基团赋予贴片高组织粘附性和体内自愈能力。这些特性赋予仿生贴片在生物医学应用中的巨大潜力。