The human body’s response to stress can contribute to metabolic dysfunction, inflammation, and cancer. Roger J. Davis has spent his career elucidating the mechanisms underlying such stress responses. A professor of molecular medicine at the University of Massachusetts Medical School at Worcester, Davis was elected to the National Academy of Sciences in 2018. His landmark work on stress-activated signaling includes deciphering the mechanisms of action and function of the first human stress-activated MAP kinase, the cJun NH2-terminal kinase (JNK), which is implicated in various disease processes. In his Inaugural Article (1), Davis and his colleagues investigated the role of IL-6–mediated signaling in chronic low-grade inflammation, which can lead to metabolic syndrome. He recently spoke to PNAS about his findings.

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与Roger J.Davis的QnA。

人体对压力的反应可能导致代谢功能障碍，炎症和癌症。罗杰·J·戴维斯（Roger J.Davis）在其职业生涯中一直在阐明这种压力反应的机制。麻省医学院在伍斯特大学的分子医学教授，戴维斯当选为美国国家科学院2018年他在应激激活的信号具有里程碑意义的工作包括破译人类第一次的动作和功能的机制应激活化MAP激酶是cJun NH2末端激酶（JNK），与各种疾病过程有关。在他的就职演说中（1），戴维斯和他的同事研究了IL-6介导的信号在慢性低度炎症中的作用，这种炎症可导致代谢综合征。他最近与PNAS谈了他的发现。