The epigenetic and functional reprogramming of immune genes during induction of trained immunity is accompanied by the metabolic rewiring of cellular state. This memory is induced in the hematopoietic niche and propagated to daughter cells, generating epigenetically and metabolically reprogrammed innate immune cells that are greatly enhanced in their capacity to resolve inflammation. In particular, these cells show accumulation of H3K4me3 and H3K27Ac epigenetic marks on multiple immune gene promoters and associated enhancers. However, the mechanism governing how these epigenetic marks accumulate at discrete immune gene loci has been poorly understood, until now. Here, we discuss some recent advances in the regulation of trained immunity, with a particular focus on the mechanistic role of a novel class of long non-coding RNAs in the establishment of epigenetic marks on trained immune gene promoters.

中文翻译：

---

在了解先天免疫记忆的分子调控方面的进展。

在诱导训练的免疫力过程中免疫基因的表观遗传和功能重编程伴随着细胞状态的代谢重排。这种记忆在造血生境中被诱导并传播到子代细胞，从而产生表观遗传和代谢重新编程的先天免疫细胞，从而大大增强了它们解决炎症的能力。特别地，这些细胞在多个免疫基因启动子和相关的增强子上显示出H3K4me3和H3K27Ac表观遗传标记的积累。然而，到目前为止，控制这些表观遗传标记如何在离散的免疫基因位点积累的机制还鲜为人知。在这里，我们讨论了训练有素的免疫力调节的最新进展，