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Fatty acid metabolism in the progression and resolution of CNS disorders.
Advanced Drug Delivery Reviews ( IF 15.2 ) Pub Date : 2020-01-25 , DOI: 10.1016/j.addr.2020.01.004 Jeroen F J Bogie 1 , Mansour Haidar 1 , Gijs Kooij 2 , Jerome J A Hendriks 1
Advanced Drug Delivery Reviews ( IF 15.2 ) Pub Date : 2020-01-25 , DOI: 10.1016/j.addr.2020.01.004 Jeroen F J Bogie 1 , Mansour Haidar 1 , Gijs Kooij 2 , Jerome J A Hendriks 1
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Recent advances in lipidomics and metabolomics have unveiled the complexity of fatty acid metabolism and the fatty acid lipidome in health and disease. A growing body of evidence indicates that imbalances in the metabolism and level of fatty acids drive the initiation and progression of central nervous system (CNS) disorders such as multiple sclerosis, Alzheimer's disease, and Parkinson's disease. Here, we provide an in-depth overview on the impact of the β-oxidation, synthesis, desaturation, elongation, and peroxidation of fatty acids on the pathophysiology of these and other neurological disorders. Furthermore, we discuss the impact of individual fatty acids species, acquired through the diet or endogenously synthesized in mammals, on neuroinflammation, neurodegeneration, and CNS repair. The findings discussed in this review highlight the therapeutic potential of modulators of fatty acid metabolism and the fatty acid lipidome in CNS disorders, and underscore the diagnostic value of lipidome signatures in these diseases.
中文翻译：
中枢神经系统疾病进展和消退中的脂肪酸代谢。
脂质组学和代谢组学的最新进展揭示了脂肪酸代谢的复杂性以及健康和疾病中的脂肪酸脂质组。越来越多的证据表明，脂肪酸代谢和水平的不平衡会导致中枢神经系统 (CNS) 疾病的发生和发展，例如多发性硬化症、阿尔茨海默病和帕金森病。在这里，我们深入概述了脂肪酸的 β-氧化、合成、去饱和、延长和过氧化对这些和其他神经系统疾病的病理生理学的影响。此外，我们讨论了通过饮食获得或在哺乳动物中内源合成的单个脂肪酸种类对神经炎症、神经变性和中枢神经系统修复的影响。
更新日期：2020-04-20
中文翻译：
中枢神经系统疾病进展和消退中的脂肪酸代谢。
脂质组学和代谢组学的最新进展揭示了脂肪酸代谢的复杂性以及健康和疾病中的脂肪酸脂质组。越来越多的证据表明，脂肪酸代谢和水平的不平衡会导致中枢神经系统 (CNS) 疾病的发生和发展，例如多发性硬化症、阿尔茨海默病和帕金森病。在这里，我们深入概述了脂肪酸的 β-氧化、合成、去饱和、延长和过氧化对这些和其他神经系统疾病的病理生理学的影响。此外，我们讨论了通过饮食获得或在哺乳动物中内源合成的单个脂肪酸种类对神经炎症、神经变性和中枢神经系统修复的影响。
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