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Filling the Gap: A Correlation between Objective and Subjective Measures of Injectability.
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2020-01-24 , DOI: 10.1002/adhm.201901521 Thomas E Robinson 1 , Erik A B Hughes 1 , Aniruddha Bose 1 , Elizabeth A Cornish 1 , Jun Y Teo 1 , Neil M Eisenstein 1 , Liam M Grover 1 , Sophie C Cox 1
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2020-01-24 , DOI: 10.1002/adhm.201901521 Thomas E Robinson 1 , Erik A B Hughes 1 , Aniruddha Bose 1 , Elizabeth A Cornish 1 , Jun Y Teo 1 , Neil M Eisenstein 1 , Liam M Grover 1 , Sophie C Cox 1
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Various injectable biomaterials are developed for the minimally invasive delivery of therapeutics. Typically, a mechanical tester is used to ascertain the force required to inject these biomaterials through a given syringe-needle system. However, currently there is no method to correlate the force measured in the laboratory to the perceived effort required to perform that injection by the end user. In this article, the injection force (F) for a variety of biomaterials, displaying a range of rheological properties, is compared with the effort scores from a 50 person panel study. The maximum injection force measured at crosshead speed 1 mm s-1 is a good proxy for injection effort, with an R2 of 0.89. This correlation leads to the following conclusions: participants can easily inject 5 mL of substance for F < 12 N; considerable effort is required to inject 5 mL for 12 N < F < 38 N; great effort is required and <5 mL can be injected for 38 N < F < 64 N; and materials are entirely non-injectable for F > 64 N. These values may be used by developers of injectable biomaterials to make decisions about formulations and needle sizes early in the translational process.
中文翻译：
填补空白：可注射性的客观和主观度量之间的相关性。
开发了各种可注射的生物材料以最小程度地侵入治疗剂。通常，使用机械测试仪来确定通过给定的注射针系统注射这些生物材料所需的力。但是，目前尚没有方法可以将在实验室中测得的力与最终用户执行注射所需的感知努力相关联。在本文中，将具有多种流变特性的多种生物材料的注射力（F）与50人小组研究的努力得分进行了比较。在十字头速度1 mm s-1下测得的最大注射力很好地代表了注射力，R2为0.89。这种相关性得出以下结论：参与者可以轻松注射5 mL F <12 N的物质；注入5 mL的12 N <F <38 N需要付出很大的努力；需要付出很大的努力，对于38 N <F <64 N可以注入<5 mL；并且对于F> 64 N，材料是完全不可注射的。可注射生物材料的开发人员可以使用这些值在翻译过程的早期就配方和针头大小做出决定。
更新日期：2020-03-04
中文翻译：
填补空白：可注射性的客观和主观度量之间的相关性。
开发了各种可注射的生物材料以最小程度地侵入治疗剂。通常，使用机械测试仪来确定通过给定的注射针系统注射这些生物材料所需的力。但是，目前尚没有方法可以将在实验室中测得的力与最终用户执行注射所需的感知努力相关联。在本文中，将具有多种流变特性的多种生物材料的注射力（F）与50人小组研究的努力得分进行了比较。在十字头速度1 mm s-1下测得的最大注射力很好地代表了注射力，R2为0.89。这种相关性得出以下结论：参与者可以轻松注射5 mL F <12 N的物质；注入5 mL的12 N <F <38 N需要付出很大的努力；需要付出很大的努力，对于38 N <F <64 N可以注入<5 mL；并且对于F> 64 N，材料是完全不可注射的。可注射生物材料的开发人员可以使用这些值在翻译过程的早期就配方和针头大小做出决定。
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