The underlying pathologies of sickle cell disease and asthma share many characteristics in terms of respiratory inflammation. The principal mechanisms of pulmonary inflammation are largely distinct, but activation of common pathways downstream of the initial inflammatory triggers may lead to exacerbation of both disease states. The altered inflammatory landscape of these respiratory pathologies can differentially impact respiratory pathogen susceptibility in patients with sickle cell disease and asthma. How these two distinct diseases behave in a comorbid setting can further exacerbate pulmonary complications associated with both disease states and impact susceptibility to respiratory infection. This review will provide a concise overview of how asthma distinctly affects individuals with sickle cell disease and how pulmonary physiology and inflammation are impacted during comorbidity.

中文翻译：

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过敏性哮喘和镰状细胞病中炎症途径的融合。

镰状细胞疾病和哮喘的潜在病理学在呼吸道炎症方面具有许多特征。肺部炎症的主要机制在很大程度上是不同的，但初始炎症触发下游的常见途径的激活可能导致两种疾病状态的恶化。这些呼吸道病理学改变后的炎症状况可以不同地影响镰状细胞病和哮喘患者的呼吸道病原体敏感性。这两种不同疾病在合并症中的表现会进一步加重与两种疾病状态相关的肺部并发症，并影响呼吸道感染的易感性。