Varicella zoster virus (VZV) is the causative agent of chickenpox (varicella) and shingles (herpes zoster). VZV and other members of the herpesvirus family are distinguished by their ability to establish a latent infection, with the potential to reactivate and spread virus to other susceptible individuals. This lifelong relationship continually subjects VZV to the host immune system and as such VZV has evolved a plethora of strategies to evade and manipulate the immune response. This review will focus on our current understanding of the innate anti-viral control mechanisms faced by VZV. We will also discuss the diverse array of strategies employed by VZV to regulate these innate immune responses and highlight new knowledge on the interactions between VZV and human innate immune cells.

中文翻译：

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水痘带状疱疹病毒对先天免疫应答的操纵。

水痘带状疱疹病毒（VZV）是水痘（水痘）和带状疱疹（带状疱疹）的病原体。VZV和疱疹病毒家族的其他成员以建立潜在感染的能力而著称，并具有将病毒重新激活并传播给其他易感个体的潜力。这种终生的关系使VZV不断受到宿主免疫系统的影响，因此VZV已经发展出许多策略来逃避和操纵免疫反应。这篇综述将集中在我们目前对VZV面临的先天抗病毒控制机制的理解上。我们还将讨论VZV用来调节这些先天免疫应答的各种策略，并重点介绍VZV与人类先天免疫细胞之间相互作用的新知识。