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Optical coherence tomography angiography findings of type 1 diabetic patients with diabetic retinopathy, in comparison with type 2 patients.
Graefe's Archive for Clinical and Experimental Ophthalmology ( IF 2.4 ) Pub Date : 2019-12-12 , DOI: 10.1007/s00417-019-04517-6
Taewoong Um 1 , Eoi Jong Seo 2 , Yoon Jeon Kim 3 , Young Hee Yoon 3
Affiliation  

PURPOSE To compare optical coherence tomography angiography (OCT-A) parameters between type 1 and type 2 diabetic patients with diabetic retinopathy (DR). METHODS A total of 70 patients with type 1 diabetes and 70 with type 2 diabetes were retrospectively analyzed. DR was graded as no DR, mild nonproliferative DR (NPDR), moderate NPDR, severe NPDR, and proliferative DR (PDR). Using OCT-A, the foveal avascular zone (FAZ) area (mm2) and vascular density (VD) (%) were calculated in the superficial capillary plexus (SCP) and deep capillary plexus (DCP). RESULTS In both type 1 and 2 diabetes patients, the FAZ area (mm2) in both capillary plexuses (CP) increased with DR progression, whereas the VD (%) progressively decreased. The changes in the FAZ area and the VD were significantly greater in the DCP than in the SCP in both types of diabetes patients(p < 0.001). In the analysis of decreasing slope of the VD in the DCP, attenuation was not significant until severe NPDR stage but then abruptly decreased when it progressed to PDR stage in type 1 diabetes. In type 2 diabetes, the DCP VD decreased gradually as DR stage progressed. CONCLUSIONS As DR progression, the increasing in FAZ area and the decreasing in VD are more severe in the DCP than in the SCP in both types of diabetes. In type 1 diabetes eyes, they were remained in relatively healthy until it gets to the advanced stage of DR, while the gradual deterioration of FAZ area and VD was found from the early stage to the advanced stage of DR in type 2 diabetes.

中文翻译:

与2型患者相比,糖尿病1型糖尿病视网膜病变患者的光学相干断层扫描血管造影结果。

目的比较1型和2型糖尿病视网膜病变(DR)糖尿病患者的光学相干断层扫描血管造影(OCT-A)参数。方法回顾性分析70例1型糖尿病患者和70例2型糖尿病患者。DR分为无DR,轻度非增殖性DR(NPDR),中度NPDR,严重NPDR和增殖性DR(PDR)。使用OCT-A计算浅表毛细血管丛(SCP)和深毛细血管丛(DCP)的中心凹无血管区(FAZ)面积(mm2)和血管密度(VD)(%)。结果在1型和2型糖尿病患者中,两个毛细血管丛(CP)的FAZ面积(mm2)随DR进展而增加,而VD(%)逐渐降低。在两种类型的糖尿病患者中,DCP的FAZ区域和VD的变化均显着大于SCP(p <0.001)。在DCP中VD斜率减小的分析中,衰减直到1级糖尿病患者直到严重的NPDR分期都没有显着性,然后在发展到PDR分期时急剧下降。在2型糖尿病中,DCP VD随着DR分期的进行而逐渐降低。结论随着DR进展,在两种类型的糖尿病中DCP的FAZ面积增加和VD的降低都比SCP更严重。在1型糖尿病眼中,它们一直处于相对健康状态,直到达到DR的晚期,而在2型糖尿病的DR的早期到晚期,发现FAZ区域和VD逐渐恶化。在DCP中VD斜率减小的分析中,衰减直到1级糖尿病患者直到严重的NPDR分期都没有显着性,然后在发展到PDR分期时急剧下降。在2型糖尿病中,DCP VD随着DR分期的进行而逐渐降低。结论在两种糖尿病中,随着DR进展,DCP的FAZ面积增加和VD的降低比SCP更严重。在1型糖尿病眼中,它们一直处于相对健康状态,直到达到DR的晚期,而在2型糖尿病的DR的早期到晚期,发现FAZ区域和VD逐渐恶化。在DCP中VD斜率减小的分析中,衰减直到1级糖尿病患者直到严重的NPDR分期都没有显着性,然后在发展到PDR分期时急剧下降。在2型糖尿病中,DCP VD随着DR分期的进行而逐渐降低。结论随着DR进展,在两种类型的糖尿病中DCP的FAZ面积增加和VD的降低都比SCP更严重。在1型糖尿病眼中,它们一直处于相对健康状态,直到达到DR的晚期,而在2型糖尿病的DR的早期到晚期,发现FAZ区域和VD逐渐恶化。随着DR阶段的进行,DCP VD逐渐降低。结论随着DR进展,在两种类型的糖尿病中DCP的FAZ面积增加和VD的降低都比SCP更严重。在1型糖尿病眼中,它们一直处于相对健康状态,直到达到DR的晚期,而在2型糖尿病的DR的早期到晚期,发现FAZ区域和VD逐渐恶化。随着DR阶段的进行,DCP VD逐渐降低。结论随着DR进展,在两种类型的糖尿病中DCP的FAZ面积增加和VD的降低都比SCP更严重。在1型糖尿病眼中,它们一直处于相对健康状态,直到达到DR的晚期,而在2型糖尿病的DR的早期到晚期,发现FAZ区域和VD逐渐恶化。
更新日期:2020-01-24
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