AIMS To evaluate changes in the segmented retinal layers of pituitary adenoma (PA) patients and to identify the relationship between these changes and visual function. METHODS A total of 47 (PA patients) and 22 (healthy subjects) eyes were reviewed from the medical records. The PA patients performed a visual field (VF) test before surgery and 1 month after surgery. By optical coherence tomography scanning, eight retinal layers were measured: retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), outer plexiform layer, outer nuclear layer, retinal pigment epithelium, and photoreceptor layer. RESULTS The PA group showed reduced RNFL, GCL, and IPL thicknesses (p = 0.004,< 0.001,< 0.001) and thicker INL thickness (p = 0.012) than did the controls. The mean deviation of preoperative VF in the PA group was positively correlated with RNFL, GCL, and IPL thicknesses (R = 0.664, 0.720, 0.664; p < 0.001,< 0.001,< 0.001) and negatively correlated with the INL thickness (R = -0.400; p = 0.010). Among the 47 eyes, 32 eyes (68%) were included for subgroup analysis. Preoperative RNFL, GCL, and IPL thicknesses were thicker in the postoperatively improved VF group (p = 0.019, 0.009, 0.005). The preoperative cutoff values for visual recovery were 23.6 μm for RNFL thickness, 30.6 μm for GCL thickness, and 28.9 μm for IPL thickness. CONCLUSION During chiasmal compression, the thickening of the INL has presented in addition to thinning of the inner retinal layers. Also, changes in retinal anatomical structures are related to the extent of VF defect and can be used as a predictor of postoperative visual recovery.

中文翻译：

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垂体腺瘤患者大裂性压缩性视神经病变的分段视网膜层分析。

目的评估垂体腺瘤（PA）患者的视网膜分割层中的变化，并确定这些变化与视觉功能之间的关系。方法从病历中对47只（PA患者）和22只（健康受试者）眼睛进行了检查。PA患者在手术前和手术后1个月进行了视野（VF）测试。通过光学相干断层扫描，测量了八个视网膜层：视网膜神经纤维层（RNFL），神经节细胞层（GCL），内部丛状层（IPL），内部核层（INL），外部丛状层，外部核层，视网膜色素上皮和感光层。结果与对照组相比，PA组的RNFL，GCL和IPL厚度降低（p = 0.004，<0.001，<0.001），INL厚度更厚（p = 0.012）。PA组术前VF的平均偏差与RNFL，GCL和IPL厚度呈正相关（R = 0.664、0.720、0.664； p <0.001，<0.001，<0.001），与INL厚度呈负相关（R = -0.400； p = 0.010）。在47眼中，包括32眼（68％）用于亚组分析。术后VF组术前RNFL，GCL和IPL厚度较厚（p = 0.019，0.009，0.005）。视觉恢复的术前截止值对于RNFL厚度为23.6μm，对于GCL厚度为30.6μm，对于IPL厚度为28.9μm。结论在颊骨压迫过程中，除了视网膜内层变薄之外，INL也出现增厚。也，