OBJECTIVE To assess the influence of biphasic calcium phosphate materials with different surface topographies on bone formation and osseointegration of titanium implants in standardized alveolar ridge defects. MATERIALS AND METHODS Standardized alveolar ridge defects (6 × 6 mm) were created in the mandible of 8 minipigs and filled with three biphasic calcium phosphate materials (BCP1-3, 90% tricalcium phosphate/10% hydroxyapatite) with different surface properties (micro- and macroporosities) as well as a bovine-derived natural bone mineral (NBM) as a control. At 12 weeks, implants were placed into the augmented defects. After further 8 weeks of healing, dissected blocks were processed for histological analysis (e.g., mineralized (MT), residual bone graft material (BS), bone-to-implant contact (BIC)). RESULTS All four biomaterials showed well-integrated graft particles and new bone formation within the defect area. MT values were comparable in all groups. BS values were highest in the NBM group (21.25 ± 13.52%) and markedly reduced in the different BCP groups, reaching statistical significance at BCP1-treated sites (9.2 ± 3.28%). All test and control groups investigated revealed comparable and statistically not significant different BIC values, ranging from 73.38 ± 20.5% (BCP2) to 84.11 ± 7.84% (BCP1), respectively. CONCLUSION All bone graft materials facilitated new bone formation and osseointegration after 12 + 8 weeks of healing.

中文翻译：

---

在minipig模型中使用具有不同表面形貌的双相磷酸钙材料在缺损再生后分阶段植入植入物。

目的评估表面形貌不同的双相磷酸钙材料对标准化牙槽缺损钛植入物骨形成和骨整合的影响。材料与方法在8头小猪的下颌骨中形成标准的牙槽缺损（6×6 mm），并用三种具有不同表面特性（微粉尘，和大孔）以及以牛为原料的天然骨矿物质（NBM）作为对照。在第12周时，将植入物放置在增大的缺损处。进一步愈合8周后，对解剖的块进行处理以进行组织学分析（例如矿化（MT），残余骨移植材料（BS），骨与植入物接触（BIC））。结果所有四种生物材料在缺损区域均显示出良好整合的移植颗粒和新的骨形成。MT值在所有组中都是可比的。在NBM组中，BS值最高（21.25±13.52％），在不同的BCP组中明显降低，在BCP1处理的部位达到统计学显着（9.2±3.28％）。研究的所有测试组和对照组均显示出可比较的BIC值，但在统计学上无显着性差异，分别从73.38±20.5％（BCP2）到84.11±7.84％（BCP1）。结论所有骨移植材料均在愈合12 + 8周后促进了新的骨形成和骨整合。52％），并且在不同的BCP组中显着减少，在BCP1处理的部位达到统计学显着性（9.2±3.28％）。研究的所有测试组和对照组均显示出可比较的BIC值，但在统计学上无显着性差异，分别从73.38±20.5％（BCP2）到84.11±7.84％（BCP1）。结论所有骨移植材料均在愈合12 + 8周后促进了新的骨形成和骨整合。52％），在不同的BCP组中显着降低，在BCP1处理的部位达到统计学显着性（9.2±3.28％）。研究的所有测试组和对照组均显示出可比较的BIC值，但在统计学上无显着性差异，分别从73.38±20.5％（BCP2）到84.11±7.84％（BCP1）。结论所有骨移植材料均在愈合12 + 8周后促进了新的骨形成和骨整合。