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Preparation of 2-Arylquinolines from 2-Arylethyl Bromides and Aromatic Nitriles with Magnesium and N-Iodosuccinimide
Synthesis ( IF 2.2 ) Pub Date : 2020-01-23 , DOI: 10.1055/s-0039-1691642 Hiroki Naruto , Hideo Togo 1
Synthesis ( IF 2.2 ) Pub Date : 2020-01-23 , DOI: 10.1055/s-0039-1691642 Hiroki Naruto , Hideo Togo 1
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Treatment of 2-arylethylmagnesium bromides, prepared from 2-arylethyl bromides and magnesium, with aromatic nitriles, followed by reaction with water and then with N-iodosuccinimide under irradiation with a tungsten lamp, gave the corresponding 2-arylquinolines in good to moderate yields under transition-metal-free conditions. 2-Alkylquinolines could be also obtained in moderate yields by the same procedure with 2-arylethyl bromides, magnesium, aliphatic nitriles bearing a secondary alkyl group, and N-iodosuccinimide.
中文翻译：
由2-芳乙基溴化物和芳族腈与镁和N-碘代琥珀酰亚胺制备2-芳基喹啉
由2-芳基乙基溴化物和镁制得的2-芳基乙基溴化镁用芳族腈处理，然后与水反应，然后与N-碘代琥珀酰亚胺在钨丝灯照射下反应，得到相应的2-芳基喹啉，在室温下收率良好至中等。无过渡金属的条件。用2-芳基乙基溴化物，镁，带有仲烷基的脂族腈和N-碘代琥珀酰亚胺也可以通过相同的方法以中等收率获得2-烷基喹啉。
更新日期：2020-01-24
中文翻译：
由2-芳乙基溴化物和芳族腈与镁和N-碘代琥珀酰亚胺制备2-芳基喹啉
由2-芳基乙基溴化物和镁制得的2-芳基乙基溴化镁用芳族腈处理，然后与水反应，然后与N-碘代琥珀酰亚胺在钨丝灯照射下反应，得到相应的2-芳基喹啉，在室温下收率良好至中等。无过渡金属的条件。用2-芳基乙基溴化物，镁，带有仲烷基的脂族腈和N-碘代琥珀酰亚胺也可以通过相同的方法以中等收率获得2-烷基喹啉。
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