Which neural circuits undergo synaptic changes when an animal learns? Although it is widely accepted that changes in synaptic strength underlie many forms of learning and memory, it remains challenging to connect changes in synaptic strength at specific neural pathways to specific behaviors and memories. Here we introduce SYNPLA (synaptic proximity ligation assay), a synapse-specific, high-throughput, and potentially brain-wide method capable of detecting circuit-specific learning-induced synaptic plasticity.

中文翻译：

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SYNPLA，一种用于识别学习后可塑性的突触的方法。

动物学习时，哪些神经回路发生突触变化？尽管人们普遍认为，突触强度的变化是许多形式的学习和记忆的基础，但将特定神经途径的突触强度的变化与特定行为和记忆联系起来仍然具有挑战性。在这里，我们介绍SYNPLA（突触邻近结扎法），一种特定于突触的，高通量且可能在全脑范围内的方法，能够检测特定于电路的学习引起的突触可塑性。