In this work, an innovative drug delivery system based on cyclic RGD-modified (as the targeting agent) and doxorubicin-loaded graphene quantum dots (R–[email protected]) was fabricated for chemo-photothermal combination therapy. These tasks include drug loading capacity, photothermal efficiency, cellular uptake and combination therapeutic effect of R–[email protected] The structure of R–[email protected] was characterized by FT-IR spectrum, UV-vis spectrum and AFM. The results indicated that the doxorubicin (DOX) could be loaded onto graphene quantum dots (GQDs) via van der Waals interaction (π–π stacking) and the drug loading capacity was 96.6% (wt). The R–[email protected] not only showed obvious pH-responsive release of DOX, but also exhibited great photothermal efficacy for cancer cells. The fluorescence intensity indicated that R–[email protected] was effectively taken up by SK–mel–5 and H460 cells. The combination of chemotherapy and photothermal therapy could more effectively inhibit growth of tumor cells, compared to photothermal therapy or chemotherapy alone.

在这项工作中，制造了一种基于环状RGD修饰的（作为靶向剂）和载有阿霉素的石墨烯量子点（R– [受电子邮件保护]）的创新药物递送系统，用于化学光热联合疗法。这些任务包括R– [受电子邮件保护的]的载药量，光热效率，细胞吸收和联合治疗效果。R– [受电子邮件保护的]结构通过FT-IR光谱，UV-vis光谱和AFM表征。结果表明，可以通过范德华相互作用（π-π堆积）将阿霉素（DOX）装载到石墨烯量子点（GQDs）上，载药量为96.6％（wt）。R– [受电子邮件保护]不仅显示出明显的pH响应释放DOX，而且还显示出对癌细胞的强大光热功效。荧光强度表明R– [电子邮件保护]被SK–mel–5和H460细胞有效吸收。与单独的光热疗法或化学疗法相比，化学疗法和光化学疗法的组合可以更有效地抑制肿瘤细胞的生长。