TSLP and IL‐33 reciprocally promote each other’s lung protein expression and ILC2 receptor expression to enhance innate type‐2 airway inflammation,Allergy

当前位置： X-MOL 学术 › Allergy › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

TSLP and IL‐33 reciprocally promote each other’s lung protein expression and ILC2 receptor expression to enhance innate type‐2 airway inflammation
Allergy ( IF 12.6 ) Pub Date : 2020-02-24 , DOI: 10.1111/all.14196
Shinji Toki ₁ , Kasia Goleniewska ₁ , Jian Zhang ₁ , Weisong Zhou ₁ , Dawn C Newcomb _{1,

2} , Baohua Zhou ₃ , Hirohito Kita ₄ , Kelli L Boyd ₂ , Ray S Peebles _{1,

2}

Affiliation

The epithelial cell‐derived danger signal mediators thymic stromal lymphopoietin (TSLP) and IL‐33 are consistently associated with adaptive Th2 immune responses in asthma. In addition, TSLP and IL‐33 synergistically promoted group 2 innate lymphoid cell (ILC2) activation to induce innate allergic inflammation. However, the mechanism of this synergistic ILC2 activation is unknown.

中文翻译：

TSLP 和 IL-33 相互促进对方肺蛋白表达和 ILC2 受体表达增强先天 2 型气道炎症

上皮细胞衍生的危险信号介导胸腺基质淋巴细胞生成素 (TSLP) 和 IL-33 始终与哮喘中的适应性 Th2 免疫反应相关。此外，TSLP 和 IL-33 协同促进第 2 组先天性淋巴样细胞 (ILC2) 活化，从而诱导先天性过敏性炎症。然而，这种协同 ILC2 激活的机制尚不清楚。

更新日期：2020-02-24

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南11