Clinical periodontal and dental findings in liver transplant patients: a systematic review and meta-analysis.,British Dental Journal

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Clinical periodontal and dental findings in liver transplant patients: a systematic review and meta-analysis.
British Dental Journal ( IF 2.0 ) Pub Date : 2020-01-01 , DOI: 10.1038/s41415-020-1196-4
Andreea Cristiana Didilescu ₁ , Adelina Lazu ₁ , Corien Pronk ₂ , Raluca Paula Vacaru ₁ , Henk S Brand ₂

Affiliation

Objectives This systematic review aimed to investigate the oral health of post-liver transplant recipients (postLTx), in terms of dental and periodontal clinical results.Data sources Pubmed/MEDLINE and Cochrane Library databases were searched electronically.Data selection Prospective, cross-sectional and case-control studies comparing periodontal and dental health of postLTx patients with healthy and/or pre-liver transplant patients.Data extraction This was performed independently by two authors. Quality assessment was done by using tools from the National Heart, Lung, and Blood Institute.Data synthesis Nine studies were eligible for inclusion in the systematic review. A meta-analysis was performed on gingival inflammation, expressed by scores, on four studies including healthy controls. The gingival index scores were significantly higher in postLTx patients compared with healthy controls (p <0.001). The weighted mean difference was 0.91 (95% confidence interval, 0.44 to 1.38, heterogeneity I2 = 99.5%). Increased tendency of gingival enlargement was noticed in postLTx patients, especially after immunosuppression with Cyclosporine A. Controversial results were reported for the prevalence of caries in postLTx recipients, but there seems to be an increase.Conclusion The results suggest that patients with liver transplants, due to systemic condition and immunosuppressive therapy, exhibit a higher degree of gingival inflammation compared with unexposed patients.Prospero registration number: CRD42019121893.

中文翻译：

肝移植患者的临床牙周和牙科检查结果：系统评价和荟萃分析。

目的本系统综述旨在从牙科和牙周临床结果的角度研究肝移植后接受者（postLTx）的口腔健康。数据来源电子检索Pubmed / MEDLINE和Cochrane Library数据库。数据选择前瞻性，横断面和病例对照研究比较了LTxpost患者与健康和/或肝移植前患者的牙周和牙齿健康。数据提取这是由两位作者独立进行的。使用国家心脏，肺和血液研究所的工具进行质量评估。数据合成9项研究符合纳入系统评价的资格。对包括健康对照组在内的四项研究进行了以分数表示的牙龈炎症的荟萃分析。与健康对照组相比，LTx后患者的牙龈指数得分显着更高（p <0.001）。加权平均差为0.91（95％置信区间，0.44至1.38，异质性I2 = 99.5％）。在LTx术后的患者中，尤其是在用环孢霉素A进行免疫抑制后，发现了牙龈增大的趋势增加。据报道，在LTLTx术后接受者的龋齿患病率存在争议，但似乎有所增加。与未暴露的患者相比，接受全身性疾病和免疫抑制治疗的患者牙龈发炎的程度更高.Prospero注册号：CRD42019121893。44至1.38，异质性I2 = 99.5％）。在LTx术后的患者中，尤其是在用环孢霉素A进行免疫抑制后，发现了牙龈增大的趋势增加。据报道，在LTLTx术后接受者的龋齿患病率存在争议，但似乎有所增加。与未暴露的患者相比，接受全身性疾病和免疫抑制治疗的患者牙龈发炎的程度更高.Prospero注册号：CRD42019121893。44至1.38，异质性I2 = 99.5％）。在LTx术后的患者中，尤其是在用环孢霉素A进行免疫抑制后，发现了牙龈增大的趋势增加。据报道，在LTLTx术后接受者的龋齿患病率存在争议，但似乎有所增加。与未暴露的患者相比，接受全身性疾病和免疫抑制治疗的患者牙龈发炎的程度更高.Prospero注册号：CRD42019121893。

更新日期：2020-01-24

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