Prepregnant Obesity of Mothers in a Multiethnic Cohort Is Associated with Cord Blood Metabolomic Changes in Offspring.,Journal of Proteome Research

当前位置： X-MOL 学术 › J. Proteome Res. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Prepregnant Obesity of Mothers in a Multiethnic Cohort Is Associated with Cord Blood Metabolomic Changes in Offspring.
Journal of Proteome Research ( IF 3.8 ) Pub Date : 2020-01-24 , DOI: 10.1021/acs.jproteome.9b00319
Ryan J Schlueter ₁ , Fadhl M Al-Akwaa ₂ , Paula A Benny ₃ , Alexandra Gurary ₄ , Guoxiang Xie ₅ , Wei Jia ₅ , Shaw J Chun ₃ , Ingrid Chern ₁ , Lana X Garmire ₂

Affiliation

Maternal obesity has become a growing global health concern that may predispose the offspring to medical conditions later in life. However, the metabolic link between maternal prepregnant obesity and healthy offspring has not yet been fully elucidated. In this study, we conducted a case-control study using a coupled untargeted and targeted metabolomic approach from the newborn cord blood metabolomes associated with a matched maternal prepregnant obesity cohort of 28 cases and 29 controls. The subjects were recruited from multiethnic populations in Hawaii, including rarely reported Native Hawaiian and other Pacific Islanders (NHPI). We found that maternal obesity was the most important factor contributing to differences in cord blood metabolomics. Using an elastic net regularization-based logistic regression model, we identified 29 metabolites as potential early-life biomarkers manifesting intrauterine effect of maternal obesity, with accuracy as high as 0.947 after adjusting for clinical confounding (maternal and paternal age, ethnicity, parity, and gravidity). We validated the model results in a subsequent set of samples (N = 30) with an accuracy of 0.822. Among the metabolites, six metabolites (galactonic acid, butenylcarnitine, 2-hydroxy-3-methylbutyric acid, phosphatidylcholine diacyl C40:3, 1,5-anhydrosorbitol, and phosphatidylcholine acyl-alkyl 40:3) were individually and significantly different between the maternal obese and normal-weight groups. Interestingly, hydroxy-3-methylbutyric acid showed significantly higher levels in cord blood from the NHPI group compared to that from Asian and Caucasian groups. In summary, significant associations were observed between maternal prepregnant obesity and offspring metabolomic alternation at birth, revealing the intergenerational impact of maternal obesity.

中文翻译：

多族裔母亲的孕妇肥胖与后代脐带血代谢组学改变有关。

孕产妇肥胖已成为全球对健康日益关注的问题，可能使后代在以后的生活中易患医疗疾病。然而，孕妇肥胖与健康后代之间的代谢联系尚未完全阐明。在这项研究中，我们进行了一项病例对照研究，该研究使用了来自新生儿脐带血代谢组的配对的非靶向和靶向代谢组学方法，与28例孕妇和29例对照孕妇相匹配。这些受试者是从夏威夷的多种族人群中招募的，其中包括鲜有报道的夏威夷原住民和其他太平洋岛民（NHPI）。我们发现母体肥胖是导致脐血代谢组学差异的最重要因素。使用基于弹性网正则化的逻辑回归模型，我们确定了29种代谢物作为潜在的早期生物标志物，它们显示出了母亲肥胖对子宫的宫内效应，在校正了临床混杂因素（母亲和父亲的年龄，种族，同性和妊娠）后，其准确性高达0.947。我们在随后的一组样本（N = 30）中验证了模型结果，准确性为0.822。在这些代谢产物中，六个代谢产物（半乳糖酸，丁烯肉碱，2-羟基-3-甲基丁酸，磷脂酰胆碱二酰基C40：3、1,5-脱水山梨醇和磷脂酰胆碱酰基烷基40：3）之间存在显着差异肥胖和体重正常的人群。有趣的是，与亚洲人和高加索人相比，NHPI组的脐血中羟基-3-甲基丁酸的水平明显更高。综上所述，

更新日期：2020-01-24

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南11