Heart failure (HF) has been a known complication of HIV/AIDS for three decades. As the treatment of HIV has changed, so has the epidemiology and pathophysiology of HF in people with HIV (PWH). Initial manifestations of HF in uncontrolled HIV primarily included a rapidly evolving cardiomyopathy with pericardial involvement. With the widespread uptake of effective antiretroviral therapy (ART), HF in PWH has become a chronic disease reflective of the aging population and associated comorbidities, albeit with a contribution from HIV-associated chronic immune dysregulation and inflammation. Despite viral suppression, PWH remain at elevated risk for both HF with reduced ejection fraction and HF with preserved ejection fraction. In this review, we discuss the changing epidemiology and mechanisms of HF in PWH and how that may inform HF prevention in this vulnerable population.

中文翻译：

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HIV 感染者心力衰竭的流行病学、病理生理学和预防。


三十年来，心力衰竭（HF）一直是艾滋病毒/艾滋病的一种已知并发症。随着 HIV 治疗方法的改变，HIV 感染者 (PWH) 心力衰竭的流行病学和病理生理学也发生了变化。未受控制的艾滋病毒中的心力衰竭的最初表现主要包括快速发展的心肌病并累及心包。随着有效抗逆转录病毒疗法 (ART) 的广泛采用，感染者心力衰竭已成为一种反映人口老龄化和相关合并症的慢性疾病，尽管艾滋病毒相关的慢性免疫失调和炎症也是其原因之一。尽管病毒受到抑制，但射血分数降低的心衰和射血分数保留的心衰风险仍然较高。在这篇综述中，我们讨论了感染者心力衰竭流行病学和机制的变化，以及这如何为这一弱势群体的心力衰竭预防提供信息。