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Spatial attention enhances network, cellular and subthreshold responses in mouse visual cortex.
Nature Communications ( IF 14.7 ) Pub Date : 2020-01-24 , DOI: 10.1038/s41467-020-14355-4
Anderson Speed 1 , Joseph Del Rosario 1 , Navid Mikail 1 , Bilal Haider 1
Affiliation  

Internal brain states strongly modulate sensory processing during behaviour. Studies of visual processing in primates show that attention to space selectively improves behavioural and neural responses to stimuli at the attended locations. Here we develop a visual spatial task for mice that elicits behavioural improvements consistent with the effects of spatial attention, and simultaneously measure network, cellular, and subthreshold activity in primary visual cortex. During trial-by-trial behavioural improvements, local field potential (LFP) responses to stimuli detected inside the receptive field (RF) strengthen. Moreover, detection inside the RF selectively enhances excitatory and inhibitory neuron responses to task-irrelevant stimuli and suppresses noise correlations and low frequency LFP fluctuations. Whole-cell patch-clamp recordings reveal that detection inside the RF increases synaptic activity that depolarizes membrane potential responses at the behaviorally relevant location. Our study establishes that mice display fundamental signatures of visual spatial attention spanning behavioral, network, cellular, and synaptic levels, providing new insight into rapid cognitive enhancement of sensory signals in visual cortex.

中文翻译:

空间注意力增强了小鼠视觉皮层中的网络,细胞和亚阈值反应。

内部大脑状态在行为过程中强烈调节感觉处理。对灵长类动物视觉处理的研究表明,对空间的关注选择性地改善了所参与位置对刺激的行为和神经反应。在这里,我们为小鼠开发了视觉空间任务,该任务引起了与空间注意力影响相一致的行为改善,并同时测量了主要视觉皮层中的网络,细胞和阈下活性。在逐项试验的行为改善过程中,对感受野(RF)内检测到的刺激的局部场电势(LFP)响应增强。此外,在RF内部进行检测可以选择性地增强对与任务无关的刺激的兴奋性和抑制性神经元反应,并抑制噪声相关性和低频LFP波动。全细胞膜片钳记录显示,RF内的检测增加了突触活性,使行为相关位置的膜电位反应去极化。我们的研究建立了小鼠显示行为,网络,细胞和突触水平的视觉空间注意的基本特征,从而为视觉皮层中感觉信号的快速认知增强提供了新的见解。
更新日期:2020-01-24
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