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Isolation of Angola-like Marburg virus from Egyptian rousette bats from West Africa.
Nature Communications ( IF 14.7 ) Pub Date : 2020-01-24 , DOI: 10.1038/s41467-020-14327-8 Brian R Amman 1 , Brian H Bird 2 , Ibrahim A Bakarr 3 , James Bangura 2, 4 , Amy J Schuh 1 , Jonathan Johnny 3 , Tara K Sealy 1 , Immah Conteh 3 , Alusine H Koroma 3 , Ibrahim Foday 3 , Emmanuel Amara 4 , Abdulai A Bangura 4 , Aiah A Gbakima 5 , Alexandre Tremeau-Bravard 3 , Manjunatha Belaganahalli 3 , Jasjeet Dhanota 2 , Andrew Chow 2 , Victoria Ontiveros 2 , Alexandra Gibson 2 , Joseph Turay 4 , Ketan Patel 1 , James Graziano 1 , Camilla Bangura 3 , Emmanuel S Kamanda 3 , Augustus Osborne 3 , Emmanuel Saidu 3 , Jonathan Musa 3 , Doris Bangura 3 , Samuel Maxwell Tom Williams 3 , Richard Wadsworth 3 , Mohamed Turay 4 , Lavalie Edwin 4 , Vanessa Mereweather-Thompson 4 , Dickson Kargbo 4 , Fatmata V Bairoh 4 , Marilyn Kanu 4 , Willie Robert 4 , Victor Lungai 4 , Raoul Emeric Guetiya Wadoum 4 , Moinya Coomber 4 , Osman Kanu 4 , Amara Jambai 6 , Sorie M Kamara 7 , Celine H Taboy 1 , Tushar Singh 8 , Jonna A K Mazet 2 , Stuart T Nichol 1 , Tracey Goldstein 2 , Jonathan S Towner 1 , Aiah Lebbie 3
Nature Communications ( IF 14.7 ) Pub Date : 2020-01-24 , DOI: 10.1038/s41467-020-14327-8 Brian R Amman 1 , Brian H Bird 2 , Ibrahim A Bakarr 3 , James Bangura 2, 4 , Amy J Schuh 1 , Jonathan Johnny 3 , Tara K Sealy 1 , Immah Conteh 3 , Alusine H Koroma 3 , Ibrahim Foday 3 , Emmanuel Amara 4 , Abdulai A Bangura 4 , Aiah A Gbakima 5 , Alexandre Tremeau-Bravard 3 , Manjunatha Belaganahalli 3 , Jasjeet Dhanota 2 , Andrew Chow 2 , Victoria Ontiveros 2 , Alexandra Gibson 2 , Joseph Turay 4 , Ketan Patel 1 , James Graziano 1 , Camilla Bangura 3 , Emmanuel S Kamanda 3 , Augustus Osborne 3 , Emmanuel Saidu 3 , Jonathan Musa 3 , Doris Bangura 3 , Samuel Maxwell Tom Williams 3 , Richard Wadsworth 3 , Mohamed Turay 4 , Lavalie Edwin 4 , Vanessa Mereweather-Thompson 4 , Dickson Kargbo 4 , Fatmata V Bairoh 4 , Marilyn Kanu 4 , Willie Robert 4 , Victor Lungai 4 , Raoul Emeric Guetiya Wadoum 4 , Moinya Coomber 4 , Osman Kanu 4 , Amara Jambai 6 , Sorie M Kamara 7 , Celine H Taboy 1 , Tushar Singh 8 , Jonna A K Mazet 2 , Stuart T Nichol 1 , Tracey Goldstein 2 , Jonathan S Towner 1 , Aiah Lebbie 3
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Marburg virus (MARV) causes sporadic outbreaks of severe Marburg virus disease (MVD). Most MVD outbreaks originated in East Africa and field studies in East Africa, South Africa, Zambia, and Gabon identified the Egyptian rousette bat (ERB; Rousettus aegyptiacus) as a natural reservoir. However, the largest recorded MVD outbreak with the highest case-fatality ratio happened in 2005 in Angola, where direct spillover from bats was not shown. Here, collaborative studies by the Centers for Disease Control and Prevention, Njala University, University of California, Davis USAID-PREDICT, and the University of Makeni identify MARV circulating in ERBs in Sierra Leone. PCR, antibody and virus isolation data from 1755 bats of 42 species shows active MARV infection in approximately 2.5% of ERBs. Phylogenetic analysis identifies MARVs that are similar to the Angola strain. These results provide evidence of MARV circulation in West Africa and demonstrate the value of pathogen surveillance to identify previously undetected threats.
中文翻译：
从西非的埃及红蝠中分离出类似安哥拉的马尔堡病毒。
马尔堡病毒 (MARV) 会导致严重马尔堡病毒病 (MVD) 的零星爆发。大多数 MVD 爆发起源于东非，东非、南非、赞比亚和加蓬的实地研究确定埃及红蝠（ERB；Rousettus aegyptiacus）是天然宿主。然而，有记录以来最大规模、病死率最高的 MVD 爆发发生在 2005 年的安哥拉，但该国并未出现蝙蝠直接蔓延的情况。在此，疾病控制和预防中心、恩贾拉大学、加州大学戴维斯分校 USAID-PREDICT 和马克尼大学的合作研究确定了塞拉利昂 ERB 中循环的 MARV。来自 42 个物种 1755 只蝙蝠的 PCR、抗体和病毒分离数据显示，大约 2.5% 的 ERB 存在活跃的 MARV 感染。系统发育分析发现 MARV 与安哥拉毒株相似。这些结果提供了 MARV 在西非循环的证据，并证明了病原体监测对于识别以前未发现的威胁的价值。
更新日期：2020-01-24
中文翻译：
从西非的埃及红蝠中分离出类似安哥拉的马尔堡病毒。
马尔堡病毒 (MARV) 会导致严重马尔堡病毒病 (MVD) 的零星爆发。大多数 MVD 爆发起源于东非，东非、南非、赞比亚和加蓬的实地研究确定埃及红蝠（ERB；Rousettus aegyptiacus）是天然宿主。然而，有记录以来最大规模、病死率最高的 MVD 爆发发生在 2005 年的安哥拉，但该国并未出现蝙蝠直接蔓延的情况。在此，疾病控制和预防中心、恩贾拉大学、加州大学戴维斯分校 USAID-PREDICT 和马克尼大学的合作研究确定了塞拉利昂 ERB 中循环的 MARV。来自 42 个物种 1755 只蝙蝠的 PCR、抗体和病毒分离数据显示，大约 2.5% 的 ERB 存在活跃的 MARV 感染。系统发育分析发现 MARV 与安哥拉毒株相似。这些结果提供了 MARV 在西非循环的证据，并证明了病原体监测对于识别以前未发现的威胁的价值。
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