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The assembly and antitumor activity of lycium barbarum polysaccharide-platinum-based conjugates.
Journal of Inorganic Biochemistry ( IF 3.8 ) Pub Date : 2020-01-24 , DOI: 10.1016/j.jinorgbio.2020.111001 Ying Wang 1 , Qianqian Han 1 , Feng Bai 1 , Qiang Luo 1 , Mingliang Wu 2 , Gang Song 2 , Hongmei Zhang 2 , Yanqing Wang 2
Journal of Inorganic Biochemistry ( IF 3.8 ) Pub Date : 2020-01-24 , DOI: 10.1016/j.jinorgbio.2020.111001 Ying Wang 1 , Qianqian Han 1 , Feng Bai 1 , Qiang Luo 1 , Mingliang Wu 2 , Gang Song 2 , Hongmei Zhang 2 , Yanqing Wang 2
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In this work, the new polysaccharide-platinum conjugates of 5-aminosalicylic acid modified lycium barbarum polysaccharide linking platinum compounds were designed in order to construct an anticancer metal drug delivery system. The multiple analysis methods were used to describe the chemical structure and physical properties of the polysaccharide-metal conjugates. The results showed that 5-aminosalicylic acid successfully acted as linker which was covalently bound between polysaccharide and platinum compound. The morphology and rheological properties of polysaccharide have been changed by the formation of conjugates, which exhibited certain inhibition specificity to A549 (human lung cancer cell line). The agarose gel electrophoresis and fluorescence microscopy results demonstrated that such conjugates promoted the unwinding of DNA and could significantly damage the nucleus of A549 cells. Cell cycle analyzing the Pt complex of conjugates could cause intracellular DNA damage and induced G2 phase arrest. So, polysaccharide-platinum conjugates might find a range of applications, for example in metal anticancer drug delivery.
中文翻译：
枸杞多糖-铂基结合物的组装和抗肿瘤活性。
在这项工作中，设计了新的5-氨基水杨酸修饰的枸杞多糖与铂化合物连接的多糖-铂结合物，以构建抗癌金属药物递送系统。多种分析方法被用来描述多糖-金属结合物的化学结构和物理性质。结果表明5-氨基水杨酸成功地充当了多糖和铂化合物之间共价结合的连接基。多糖的形态和流变性质已通过结合物的形成而改变，其对A549（人肺癌细胞系）表现出一定的抑制特异性。琼脂糖凝胶电泳和荧光显微镜检查结果表明，这种结合物促进了DNA的解链并可能显着破坏A549细胞的细胞核。细胞周期分析结合物的Pt复合物可能导致细胞内DNA损伤并诱导G2期阻滞。因此，多糖-铂结合物可能会发现一系列应用，例如在金属抗癌药物的递送中。
更新日期：2020-01-24
中文翻译：
枸杞多糖-铂基结合物的组装和抗肿瘤活性。
在这项工作中，设计了新的5-氨基水杨酸修饰的枸杞多糖与铂化合物连接的多糖-铂结合物，以构建抗癌金属药物递送系统。多种分析方法被用来描述多糖-金属结合物的化学结构和物理性质。结果表明5-氨基水杨酸成功地充当了多糖和铂化合物之间共价结合的连接基。多糖的形态和流变性质已通过结合物的形成而改变，其对A549（人肺癌细胞系）表现出一定的抑制特异性。琼脂糖凝胶电泳和荧光显微镜检查结果表明，这种结合物促进了DNA的解链并可能显着破坏A549细胞的细胞核。细胞周期分析结合物的Pt复合物可能导致细胞内DNA损伤并诱导G2期阻滞。因此，多糖-铂结合物可能会发现一系列应用，例如在金属抗癌药物的递送中。
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