Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Mutual interaction between motor cortex activation and pain in fibromyalgia: EEG-fNIRS study.
PLOS ONE ( IF 2.9 ) Pub Date : 2020-01-23 , DOI: 10.1371/journal.pone.0228158 Eleonora Gentile 1 , Antonio Brunetti 2 , Katia Ricci 1 , Marianna Delussi 1 , Vitoantonio Bevilacqua 2 , Marina de Tommaso 1
PLOS ONE ( IF 2.9 ) Pub Date : 2020-01-23 , DOI: 10.1371/journal.pone.0228158 Eleonora Gentile 1 , Antonio Brunetti 2 , Katia Ricci 1 , Marianna Delussi 1 , Vitoantonio Bevilacqua 2 , Marina de Tommaso 1
Affiliation
|
BACKGROUND
Experimental and clinical studies suggested an analgesic effect on chronic pain by motor cortex activation. The present study explored the complex mechanisms of interaction between motor and pain during performing the slow and fast finger tapping task alone and in concomitant with nociceptive laser stimulation.
METHOD
The participants were 38 patients with fibromyalgia (FM) and 21 healthy subjects. We used a simultaneous multimodal method of laser-evoked potentials and functional near-infrared spectroscopy to investigate metabolic and electrical changes during the finger tapping task and concomitant noxious laser stimulation. Functional near-infrared spectroscopy is a portable and optical method to detect cortical metabolic changes. Laser-evoked potentials are a suitable tool to study the nociceptive pathways function.
RESULTS
We found a reduced tone of cortical motor areas in patients with FM compared to controls, especially during the fast finger tapping task. FM patients presented a slow motor performance in all the experimental conditions, requesting rapid movements. The amplitude of laser evoked potentials was different between patients and controls, in each experimental condition, as patients showed smaller evoked responses compared to controls. Concurrent phasic pain stimulation had a low effect on motor cortex metabolism in both groups nor motor activity changed laser evoked responses in a relevant way. There were no correlations between Functional Near-Infrared Spectroscopy (FNIRS) and clinical features in FM patients.
CONCLUSION
Our findings indicated that a low tone of motor cortex activation could be an intrinsic feature in FM and generate a scarce modulation on pain condition. A simple and repetitive movement such as that of the finger tapping task seems inefficacious in modulating cortical responses to pain both in patients and controls. The complex mechanisms of interaction between networks involved in pain control and motor function require further studies for the important role they play in structuring rehabilitation strategies.
中文翻译：
运动皮层激活与纤维肌痛疼痛之间的相互作用：EEG-fNIRS 研究。
背景技术实验和临床研究表明运动皮层激活对慢性疼痛有镇痛作用。本研究探讨了单独执行慢速和快速手指敲击任务以及伴随伤害性激光刺激时运动与疼痛之间相互作用的复杂机制。方法 参与者包括 38 名纤维肌痛 (FM) 患者和 21 名健康受试者。我们使用激光诱发电位和功能近红外光谱的同步多模态方法来研究手指敲击任务和伴随的有害激光刺激期间的代谢和电变化。功能性近红外光谱是一种检测皮质代谢变化的便携式光学方法。激光诱发电位是研究伤害性通路功能的合适工具。结果我们发现，与对照组相比，FM 患者的皮质运动区张力降低，尤其是在快速手指敲击任务期间。FM 患者在所有实验条件下均表现出缓慢的运动表现，需要快速运动。在每个实验条件下，患者和对照组之间的激光诱发电位的幅度不同，因为与对照组相比，患者表现出较小的诱发反应。同时阶段性疼痛刺激对两组运动皮层代谢影响较小，运动活动也不会以相关方式改变激光诱发反应。功能性近红外光谱 (FNIRS) 与 FM 患者的临床特征之间没有相关性。结论 我们的研究结果表明，运动皮层激活的低调可能是 FM 的内在特征，并对疼痛状况产生稀有的调节。简单且重复的动作（例如手指敲击任务）似乎无法有效调节患者和对照组的皮质对疼痛的反应。涉及疼痛控制和运动功能的网络之间相互作用的复杂机制需要进一步研究它们在构建康复策略中所发挥的重要作用。
更新日期：2020-01-24
中文翻译：
运动皮层激活与纤维肌痛疼痛之间的相互作用：EEG-fNIRS 研究。
背景技术实验和临床研究表明运动皮层激活对慢性疼痛有镇痛作用。本研究探讨了单独执行慢速和快速手指敲击任务以及伴随伤害性激光刺激时运动与疼痛之间相互作用的复杂机制。方法 参与者包括 38 名纤维肌痛 (FM) 患者和 21 名健康受试者。我们使用激光诱发电位和功能近红外光谱的同步多模态方法来研究手指敲击任务和伴随的有害激光刺激期间的代谢和电变化。功能性近红外光谱是一种检测皮质代谢变化的便携式光学方法。激光诱发电位是研究伤害性通路功能的合适工具。结果我们发现，与对照组相比，FM 患者的皮质运动区张力降低，尤其是在快速手指敲击任务期间。FM 患者在所有实验条件下均表现出缓慢的运动表现，需要快速运动。在每个实验条件下，患者和对照组之间的激光诱发电位的幅度不同，因为与对照组相比，患者表现出较小的诱发反应。同时阶段性疼痛刺激对两组运动皮层代谢影响较小，运动活动也不会以相关方式改变激光诱发反应。功能性近红外光谱 (FNIRS) 与 FM 患者的临床特征之间没有相关性。结论 我们的研究结果表明，运动皮层激活的低调可能是 FM 的内在特征，并对疼痛状况产生稀有的调节。简单且重复的动作（例如手指敲击任务）似乎无法有效调节患者和对照组的皮质对疼痛的反应。涉及疼痛控制和运动功能的网络之间相互作用的复杂机制需要进一步研究它们在构建康复策略中所发挥的重要作用。
京公网安备 11010802027423号