Recyclable Itaconic Acid with Water as Green Catalytic System: Synthesis of Substituted 1,5‐Benzodiazepine Derivatives at Room Temperature,ChemistrySelect

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Recyclable Itaconic Acid with Water as Green Catalytic System: Synthesis of Substituted 1,5‐Benzodiazepine Derivatives at Room Temperature
ChemistrySelect ( IF 1.9 ) Pub Date : 2020-01-24 , DOI: 10.1002/slct.201904408
Kashyap J. Tamuli _{1,

2} , Manobjyoti Bordoloi _{1,

2}

Affiliation

The construction of new C–N chemical bonds through co‐condensation reaction in water media as sole solvent, especially without the use of any metal catalyst has undergoes green protocols. Herein, we describe a water‐mediated and metal‐free mild protocol for easily accessing of structurally and electronically diverse 1,5‐benzodiazepine analogous by using biodegradable naturally occurring itaconic acid (20 mol%) in 30 minutes with excellent yields. The simplicity in reaction operation, reusability of the catalytic system and simple filtration to get the desired product make this reaction as “green synthetic pathway” upto multi gram scale level.

中文翻译：

以水为绿色催化体系的可回收衣康酸：在室温下合成取代的1,5-苯二氮杂卓衍生物

通过在水介质中作为唯一溶剂的共缩合反应构建新的CN化学键，尤其是不使用任何金属催化剂的情况，已经通过了绿色规程。本文中，我们描述了一种水介导的，不含金属的温和规程，可通过在30分钟内使用可生物降解的天然衣康酸（20 mol％）以优异的收率轻松访问结构和电子形式多样的1,5-苯并二氮杂analog类似物。反应操作的简单性，催化体系的可重复使用性以及易于过滤以得到所需产物的方法，使该反应成为“绿色合成途径”，达到了数克规模。

更新日期：2020-01-24

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