OBJECTIVE To assess the contemporaneous prevalence of diabetic peripheral neuropathy (DPN) in people with type 1 diabetes (T1D) in Scotland and study its cross-sectional association with risk factors and other diabetic complications. RESEARCH DESIGN AND METHODS We analyzed data from a large representative sample of adults with T1D (N = 5,558). We assessed the presence of symptomatic neuropathy using the dichotomized (≥4) Michigan Screening Instrument Patient Questionnaire score. Logistic regression models were used to investigate associations between DPN and risk factors, as well as with other complications. RESULTS The burden of DPN is substantial with 13% prevalence overall. Adjusting for attained age, diabetes duration, and sex, the odds of DPN increased mainly with waist-to-hip ratio, lipids, poor glycemic control (odds ratio 1.51 [95% CI 1.21-1.89] for levels of 75 vs. 53 mmol/mol), ever versus never smoking (1.67 [1.37-2.03]), and worse renal function (1.96 [1.03-3.74] for estimated glomerular filtration rate levels <30 vs. ≥90 mL/min/1.73 m2). The odds significantly decreased with HDL-cholesterol (0.77 [0.66-0.89] per mmol/L). Living in more deprived areas was associated with DPN (2.17 [1.78-2.65]) for more versus less deprived areas adjusted for other risk factors. Finally, individuals with prevalent DPN were much more likely than others to have other diabetes complications. CONCLUSIONS Diabetic neuropathy remains substantial, particularly affecting those in the most socioeconomically deprived groups. Those with clinically manifest neuropathy also have a higher burden of other complications and elevated levels of modifiable risk factors. These data suggest that there is considerable scope to reduce neuropathy rates and narrow the socioeconomic differential by better risk factor control.

中文翻译：

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糖尿病神经病变是 1 型糖尿病患者的重大负担，并且与社会经济劣势密切相关：来自苏格兰的一项具有代表性的人口研究。

目的 评估苏格兰 1 型糖尿病 (T1D) 患者糖尿病周围神经病变 (DPN) 的同期患病率，并研究其与危险因素和其他糖尿病并发症的横断面关联。研究设计和方法 我们分析了来自 T1D 成人的大型代表性样本（N = 5,558）的数据。我们使用二分法 (≥4) 密歇根筛查工具患者问卷评分评估了有症状的神经病变的存在。Logistic 回归模型用于研究 DPN 与危险因素以及其他并发症之间的关联。结果 DPN 的负担很重，总体患病率为 13%。调整达到的年龄、糖尿病病程和性别后，DPN 的几率主要随着腰臀比、血脂、血糖控制不佳而增加（几率比 1.51 [95% CI 1. 75 与 53 mmol/mol 的水平分别为 21-1.89]、曾经吸烟与从不吸烟（1.67 [1.37-2.03]）和更差的肾功能（1.96 [1.03-3.74] 估计肾小球滤过率水平 <30 与≥90 毫升/分钟/1.73 平方米）。HDL-胆固醇的几率显着降低（0.77 [0.66-0.89] / mmol / L）。生活在更贫困地区与 DPN 相关 (2.17 [1.78-2.65])，相对于其他风险因素调整后贫困程度较低的地区。最后，患有普遍 DPN 的人比其他人更有可能患有其他糖尿病并发症。结论 糖尿病神经病变仍然很严重，特别是影响那些处于社会经济最贫困群体中的人。那些有临床表现的神经病变的人也有更高的其他并发症负担和可改变的危险因素水平升高。