Adolescence represents a key developmental period in terms of both mood and overweight and is linked to disturbed eating behavior. Therefore, it is essential to investigate the basis of food intake in healthy adolescents by considering mood impacts which remain largely unexplored. Hence this study aims to investigate the impact of hunger and mood on cerebral blood flow (CBF) changes in healthy adolescents. Fifteen participants underwent two MRI sessions including a 3D pseudo-continuous arterial spin labeling sequence: pre-lunch (hunger) and post-lunch (satiety). Mood was assessed using the Multiscore Depression Inventory for Children. We found higher CBF values in the posterior insula in response to hunger compared to satiety, an area of the brain which contributes to the anticipation and motivation of feeding. In response to satiation, we observed higher CBF values in the precuneus, lingual gyrus and cuneus which are involved in the aspects of response inhibition related to food intake. Furthermore, we show that correlation between mood assessment and CBF is modulated by appetite in the precuneus, anterior cingulate gyrus, anterior orbitofrontal gyrus, occipital gyrus and cuneus, suggesting that participants affected by depressed mood could use ruminative processing in order to evaluate the reward of an upcoming meal.

中文翻译：

---

饥饿对健康青少年大脑血流的不同影响。

青春期代表着情绪和超重的关键发展时期，并且与饮食行为受阻有关。因此，至关重要的是要通过考虑很大程度上尚未发现的情绪影响来调查健康青少年的食物摄入基础。因此，本研究旨在调查饥饿和情绪对健康青少年脑血流量（CBF）变化的影响。15名参与者进行了两次MRI疗程，包括3D伪连续动脉自旋标记序列：午餐前（饥饿）和午餐后（饱腹感）。使用儿童多分抑郁量表评估情绪。我们发现，与饱腹感相比，对饥饿的反应在后绝缘体中的CBF值更高，饱足感是大脑的一个区域，有助于预期进食和进食动机。为了满足 我们观察到前足，舌回和楔骨中的CBF值较高，这些值参与与食物摄入有关的反应抑制方面。此外，我们发现情绪评估与CBF之间的相关性受前神经元，前扣带回，前眶额回，枕回和楔形的食欲的调节，这表明受情绪低落影响的参与者可使用反刍加工来评估其奖励。一顿即将到来的饭。