The polysaccharides and phenylethanoid glycosides from Cistanche deserticola have been demonstrated with various health benefits, however the interactive effect between these two kinds of compounds in vivo are not in detail known. The objective of this study was to investigate the synergistic actions of cistanche polysaccharides with phenylethanoid glycoside and the effects of polysaccharides on gut microbiota. Sprague-Dawley rats were fed with different kinds of cistanche polysaccharides for 20 days, on the last day, all rats were administered the echinacoside at 100 mg/kg. The results were compared mainly on the difference of pharmacokinetic parameters, gut microbiota composition, and short chain fatty acids contents. The results indicated that all the cistanche polysaccharides, including crude polysaccharide, high molecular weight polysaccharide and low molecular weight polysaccharide, could regulate the gut microbiota diversity, increase beneficial bacteria and particularly enhance the growth of Prevotella spp. as well as improve the production of short chain fatty acids and the absorption of echinacoside. By exploring the synergistic actions of polysaccharides with small molecules, these findings suggest that cistanche polysaccharides, particularly low molecular weight polysaccharides, could be used as a gut microbiota manipulator for health promotion.

肉Ci蓉肉中的多糖和苯乙醛糖苷已被证明具有多种健康益处，但是，这两种化合物在体内的相互作用尚不清楚。这项研究的目的是研究肉stan蓉多糖与苯基乙醛糖苷的协同作用以及多糖对肠道菌群的影响。给Sprague-Dawley大鼠喂食不同种类的肉stan蓉多糖20天，最后一天，所有大鼠均以100 mg / kg的剂量给予紫锥菊苷。比较结果主要是在药代动力学参数，肠道菌群组成和短链脂肪酸含量的差异上。结果表明，肉蓉多糖，包括粗多糖，高分子量多糖和低分子量多糖，均能调节肠道菌群多样性，增加有益菌，特别是促进普氏菌的生长。spp。以及改善短链脂肪酸的生产和紫锥花苷的吸收。通过探索多糖与小分子的协同作用，这些发现表明肉蓉多糖，特别是低分子量多糖，可以用作促进健康的肠道菌群操纵器。