当前位置：
X-MOL 学术
›
Cell Calcium
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Structural insights into the gating mechanisms of TRPV channels.
Cell Calcium ( IF 4.3 ) Pub Date : 2020-01-24 , DOI: 10.1016/j.ceca.2020.102168 Ruth A Pumroy 1 , Edwin C Fluck 1 , Tofayel Ahmed 1 , Vera Y Moiseenkova-Bell 1
Cell Calcium ( IF 4.3 ) Pub Date : 2020-01-24 , DOI: 10.1016/j.ceca.2020.102168 Ruth A Pumroy 1 , Edwin C Fluck 1 , Tofayel Ahmed 1 , Vera Y Moiseenkova-Bell 1
Affiliation
|
Transient Receptor Potential channels from the vanilloid subfamily (TRPV) are a group of cation channels modulated by a variety of endogenous stimuli as well as a range of natural and synthetic compounds. Their roles in human health make them of keen interest, particularly from a pharmacological perspective. However, despite this interest, the complexity of these channels has made it difficult to obtain high resolution structures until recently. With the cryo-EM resolution revolution, TRPV channel structural biology has blossomed to produce dozens of structures, covering every TRPV family member and a variety of approaches to examining channel modulation. Here, we review all currently available TRPV structures and the mechanistic insights into gating that they reveal.
中文翻译：
对TRPV通道门控机制的结构见解。
来自类香草素亚家族（TRPV）的瞬态受体电位通道是一组阳离子通道，受各种内源性刺激以及一系列天然和合成化合物调节。它们在人类健康中的作用引起了人们的浓厚兴趣，特别是从药理学的角度来看。然而，尽管有这种兴趣，但是这些通道的复杂性使得直到最近才难以获得高分辨率结构。随着cryo-EM分辨率的革命，TRPV通道结构生物学蓬勃发展，产生了数十种结构，涵盖了每个TRPV家族成员以及各种检查通道调制的方法。在这里，我们回顾了所有当前可用的TRPV结构以及它们揭示的门控机理。
更新日期：2020-01-24
中文翻译：
对TRPV通道门控机制的结构见解。
来自类香草素亚家族（TRPV）的瞬态受体电位通道是一组阳离子通道，受各种内源性刺激以及一系列天然和合成化合物调节。它们在人类健康中的作用引起了人们的浓厚兴趣，特别是从药理学的角度来看。然而，尽管有这种兴趣，但是这些通道的复杂性使得直到最近才难以获得高分辨率结构。随着cryo-EM分辨率的革命，TRPV通道结构生物学蓬勃发展，产生了数十种结构，涵盖了每个TRPV家族成员以及各种检查通道调制的方法。在这里，我们回顾了所有当前可用的TRPV结构以及它们揭示的门控机理。
京公网安备 11010802027423号