当前位置：
X-MOL 学术
›
Lancet Respir. Med.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
FLT1: a potential therapeutic target in sepsis-associated ARDS?
The Lancet Respiratory Medicine ( IF 38.7 ) Pub Date : 2020-01-23 , DOI: 10.1016/s2213-2600(19)30404-7 Ian P Hall 1
The Lancet Respiratory Medicine ( IF 38.7 ) Pub Date : 2020-01-23 , DOI: 10.1016/s2213-2600(19)30404-7 Ian P Hall 1
Affiliation
|
In the past 10 years, genome-wide association studies (GWAS) have become a standard approach to improve our understanding of the aetiology of complex diseases. Many such studies have been done, and multiple associations reported for a wide range of diseases or subphenotypes. However, for most diseases, the biggest challenge remains to be addressed—moving from showing association with a genetic marker (typically a single-nucleotide polymorphism [SNP] chosen because it is informative about genetic linkage in a region of the human genome) to gaining an understanding of the functional mechanisms underlying the association.
中文翻译：
FLT1：败血症相关ARDS的潜在治疗靶点？
在过去的十年中，全基因组关联研究（GWAS）已成为提高我们对复杂疾病的病因学认识的标准方法。已经进行了许多此类研究，并且报道了多种疾病或亚表型的多种关联。但是，对于大多数疾病而言，最大的挑战仍然有待解决-从显示与遗传标记（通常是选择单核苷酸多态性[SNP]的关联，因为它有助于了解人类基因组区域的遗传连锁）转变为获得对关联基础的功能机制的理解。
更新日期：2020-03-03
中文翻译：
FLT1：败血症相关ARDS的潜在治疗靶点？
在过去的十年中，全基因组关联研究（GWAS）已成为提高我们对复杂疾病的病因学认识的标准方法。已经进行了许多此类研究，并且报道了多种疾病或亚表型的多种关联。但是，对于大多数疾病而言，最大的挑战仍然有待解决-从显示与遗传标记（通常是选择单核苷酸多态性[SNP]的关联，因为它有助于了解人类基因组区域的遗传连锁）转变为获得对关联基础的功能机制的理解。
京公网安备 11010802027423号