BACKGROUND Albuminuria is highly prevalent among older adults, especially those with diabetes. It is associated with several chronic diseases, but its overall impact on the health of older adults, as measured by hospitalization, has not been quantified. METHODS We followed 3110 adults, mean age 78 years, for a median 9.75 years, of whom 654 (21%) had albuminuria (>30 mg albumin / gram creatinine) at baseline. Poisson regression models, adjusted for cardiovascular, renal and demographic factors, were used to evaluate association of albuminuria with all-cause and cause-specific hospitalizations, as defined by ICD, version 9, categories. RESULTS The rates of hospitalization per 100 patient-years were 65.85 for participants with albuminuria and 37.55 for participants without albuminuria. After adjustment for covariates, participants with albuminuria were more likely to be hospitalized for any cause than participants without albuminuria (incident rate ratio [IRR], 1.39 [95% confidence intervals, 1.27. 1.53] and to experience more days in hospital (IRR 1.56 [1.37, 1.76]). The association of albuminuria with hospitalization was similar among participants with and without diabetes (adjusted IRR for albuminuria vs no albuminuria: diabetes 1.37 [1.11, 1.70], no diabetes 1.40 [1.26, 1.55]; p interaction NS). Albuminuria was significantly associated with hospitalization for circulatory, endocrine, genitourinary, respiratory, and injury categories. CONCLUSIONS Albuminuria in older adults is associated with an increased risk of hospitalization for a broad range of illnesses. Albuminuria in the presence or absence of diabetes appears to mark a generalized vulnerability to diseases of aging among older adults.

中文翻译：

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患有蛋白尿的老年人的住院率：心血管健康研究。


背景蛋白尿在老年人中非常普遍，尤其是患有糖尿病的老年人。它与多种慢性疾病有关，但通过住院治疗衡量，它对老年人健康的总体影响尚未量化。方法 我们对 3110 名成年人进行了随访，平均年龄 78 岁，中位时间 9.75 年，其中 654 名 (21%) 基线时有白蛋白尿 (>30 mg 白蛋白/克肌酐)。根据心血管、肾脏和人口因素进行调整后的泊松回归模型用于评估蛋白尿与全因和特定原因住院治疗的关联，如 ICD 第 9 版类别所定义。结果 有蛋白尿的参与者每 100 患者年的住院率为 65.85，无蛋白尿的参与者为 37.55。调整协变量后，有蛋白尿的参与者比没有蛋白尿的参与者更有可能因任何原因住院（发病率比 [IRR]，1.39 [95% 置信区间，1.27. 1.53]，并且住院天数更长（IRR 1.56） [1.37, 1.76]）在患有和不患有糖尿病的参与者中，蛋白尿与住院的相关性相似（蛋白尿与无蛋白尿的调整 IRR：糖尿病 1.37 [1.11, 1.70]，无糖尿病 1.40 [1.26, 1.55]；p 相互作用 NS ）。白蛋白尿与循环系统、内分泌、泌尿生殖、呼吸系统和损伤类别的住院显着相关。无论是否存在糖尿病，白蛋白尿与多种疾病的住院风险增加相关。标志着老年人普遍容易患衰老疾病。