Exposure to even very low concentration of Pb2+ can cause neurological and developmental disorders, and affects children more severely. Neuromelanin (NM) in the substantial nigra can trap endogenous and environmental toxins and immobilize them as stable adducts, thus protecting brain against toxicity. Until now, the structure and Pb2+-chelating ability of NM is still little understood. Here, we prepare a mimicking NM by amino acid and dopamine. The prepared NM has strong fluorescent and its fluorescence can be quenched by Pb2+. This study offers a novel way to synthetic NM and provides an effective method to detect Pb2+.

中文翻译：

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模拟神经黑色素纳米颗粒作为选择性 Pb2+ 探针

即使接触极低浓度的 Pb2+ 也会导致神经和发育障碍，对儿童的影响更为严重。大量黑质中的神经黑色素 (NM) 可以捕获内源性和环境毒素并将它们固定为稳定的加合物，从而保护大脑免受毒性。到目前为止，NM 的结构和 Pb2+ 螯合能力仍知之甚少。在这里，我们通过氨基酸和多巴胺制备了一个模拟 NM。制备的NM具有强荧光，其荧光可被Pb2+猝灭。该研究为合成NM提供了一种新方法，并提供了一种检测Pb2+的有效方法。