Nerves in cancer.,Nature Reviews Cancer

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Nerves in cancer.
Nature Reviews Cancer ( IF 72.5 ) Pub Date : 2020-01-23 , DOI: 10.1038/s41568-019-0237-2
Ali H Zahalka _{1,

2,

3} , Paul S Frenette _{1,

2,

4}

Affiliation

The contribution of nerves to the pathogenesis of malignancies has emerged as an important component of the tumour microenvironment. Recent studies have shown that peripheral nerves (sympathetic, parasympathetic and sensory) interact with tumour and stromal cells to promote the initiation and progression of a variety of solid and haematological malignancies. Furthermore, new evidence suggests that cancers may reactivate nerve-dependent developmental and regenerative processes to promote their growth and survival. Here we review emerging concepts and discuss the therapeutic implications of manipulating nerves and neural signalling for the prevention and treatment of cancer.

中文翻译：

癌症中的神经。

神经对恶性肿瘤发病机制的贡献已成为肿瘤微环境的重要组成部分。最近的研究表明，周围神经（交感神经、副交感神经和感觉神经）与肿瘤和基质细胞相互作用，促进多种实体和血液恶性肿瘤的发生和进展。此外，新的证据表明，癌症可能会重新激活神经依赖性发育和再生过程，以促进其生长和存活。在这里，我们回顾新兴概念，并讨论操纵神经和神经信号传导对预防和治疗癌症的治疗意义。

更新日期：2020-01-23

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