The objective of the study was to determine the relationship between serum concentrations of selenium (SeS) and zinc (ZnS), total antioxidant status (TAS) and endothelial function assessed by ultrasonographic method of dilatation of the brachial artery in 141 hypertensive patients.

Patients with SeS < median were characterized by a statistically significantly lower flow-mediated dilation (FMD) than patients with SeS ≥ median. Patients with TAS < median were characterized by a significantly lower FMD than patients with TAS ≥ median. Older age, higher BMI, male gender, higher blood total cholesterol, ischemic heart disease, smoking and lower SeS constitute independent predictors of inferior endothelial function, expressed in lower FMD values. Smoking is an independent predictor of lower TAS, and the use of β-blockers and higher serum selenium levels are independent predictors of higher TAS.

In summary, a decrease in TAS should be considered as a mechanism of inferior endothelial function in hypertensive patients conditioned by a decrease in SeS.

这项研究的目的是确定141例高血压患者的血清硒（Se ）和锌（Zn S）浓度，总抗氧化剂状态（TAS）与内皮功能之间的关系。

Se S <中位数的患者的特征在于，其血流介导的扩张（FMD）统计学上显着低于Se S≥中位数的患者。TAS <中位数的患者的FMD明显低于TAS≥中位数的患者。老年人，较高的BMI，男性，较高的血液总胆固醇，缺血性心脏病，吸烟和较低的Se S构成较低的内皮功能的独立预测因子，以较低的FMD值表示。吸烟是较低TAS的独立预测因子，而使用β受体阻滞剂和较高血清硒水平是较高TAS的独立预测因子。

总而言之，应将TAS减少视为高血压患者中Se S减少所致的内皮功能低下的机制。