Novel mechanistic links between high-protein diets and atherosclerosis.,Nature Metabolism

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Novel mechanistic links between high-protein diets and atherosclerosis.
Nature Metabolism ( IF 18.9 ) Pub Date : 2020-01-23 , DOI: 10.1038/s42255-019-0163-3
Hanrui Zhang ₁ , Muredach P Reilly _{1,

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Affiliation

New research in this issue of Nature Metabolism shows how a high-protein diet increases amino acids in blood and atherosclerotic plaques, and in plaque macrophages activates mTOR signalling, suppresses mitophagy and increases apoptosis, thereby exacerbating atherosclerotic-plaque build-up in genetically modified mouse models.

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