Liu et al. report data from the largest sequencing analysis of tumour material from patients with metastatic melanoma receiving immune-checkpoint inhibitors. These data confirm the correlations between baseline immune infiltrate and treatment response, but also demonstrate inconsistent associations of tumour mutational burden, specific gene mutations and previously described gene expression patterns with clinical outcomes.

中文翻译：

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生物学证实，但生物标志物在黑色素瘤免疫治疗中难以捉摸。

刘等。报告来自接受免疫检查点抑制剂的转移性黑色素瘤患者肿瘤材料的最大测序分析数​​据。这些数据证实了基线免疫浸润与治疗反应之间的相关性，但也证明了肿瘤突变负担，特定基因突变和先前描述的基因表达模式与临床结果之间的不一致关联。