Identification of the Side Products That Diminish the Yields of the Monoamidated Product in Metal-Catalyzed C-H Amidation of 2-Phenylpyridine with Arylisocyanates.,The Journal of Organic Chemistry

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Identification of the Side Products That Diminish the Yields of the Monoamidated Product in Metal-Catalyzed C-H Amidation of 2-Phenylpyridine with Arylisocyanates.
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2020-01-23 , DOI: 10.1021/acs.joc.9b02831
Alasdair I McKay _{1,

2} , Weam A O Altalhi _{1,

2} , Lachlan E McInnes _{1,

2} , Milena L Czyz ₁ , Allan J Canty ₃ , Paul S Donnelly _{1,

2} , Richard A J O'Hair _{1,

2}

Affiliation

The Ru(II)-catalyzed amidation of 2-arylpyridines with aryl isocyanates via C-H bond activation is less efficient than described previously, due to the formation of a series of side products, which were readily identified using direct infusion electrospray mass spectrometry and high-performance liquid chromatography-mass spectrometry.

中文翻译：

鉴定会降低2-苯基吡啶与芳基异氰酸酯在金属催化的CH酰胺化中单酰胺化产物的收率的副产物。

由于形成了一系列副产物，这些副产物可以通过直接注入电喷雾质谱法和高效液相色谱法进行快速鉴定，因此，Ru（II）通过CH键活化将2-芳基吡啶与异氰酸芳基酯催化的酰胺化反应效率不如先前所述。高效液相色谱-质谱联用。

更新日期：2020-01-23

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