Gedunin is an important limonoid present in several genera of the Meliaceae family, mainly in seeds. Several biological activities have been attributed to gedunin, including antibacterial, insecticidal, antimalarial, antiallergic, anti-inflammatory, anticancer, and neuroprotective effects. The discovery of gedunin as a heat shock protein (Hsp) inhibitor represented a very important landmark for its application as a biological therapeutic agent. The current study is a critical literature review based on the several biological activities so far described for gedunin, its therapeutic effect on some human diseases, and future directions of research for this natural compound.

中文翻译：

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楝科柠檬苦素类药物葛杜宁的生物活性

葛杜宁是一种重要的柠檬苦素类化合物，存在于楝科的几个属中，主要存在于种子中。葛杜宁具有多种生物活性，包括抗菌、杀虫、抗疟、抗过敏、抗炎、抗癌和神经保护作用。葛杜宁作为热休克蛋白 (Hsp) 抑制剂的发现对其作为生物治疗剂的应用来说是一个非常重要的里程碑。目前的研究是基于迄今为止描述的葛杜宁的几种生物活性、其对某些人类疾病的治疗作用以及这种天然化合物的未来研究方向的重要文献综述。