A series of amphiphilic polymer mPEG-PUSS-mPEG were developed by a combination of ring opening polymerization (ROP) and polyaddition reaction and its self-assembled micelles were developed for hydrophobic anticancer drugs delivery. Polymeric critical micellar concentration (CMC) values in aqueous solution were about 2.8–5.5 mg/L. And the partition equilibrium constant (K_v) of pyrene in micellar solutions ranged from 1.52 × 10⁵ to 2.20 × 10⁵. The average sizes of the self-assembled blank and DOX-loaded micelles were 160–180 nm determined by dynamic light scattering (DLS). The morphology of the DOX-loaded micelles was spherical by transmission electron microscopy (TEM) and scanning electron microscopy (SEM).The in vitro drug release behaviors of DOX and PTX from mPEG-PUSS-mPEG micelles were investigated at different simulated conditions. We found that the PTX release was significantly accelerated by redox stimuli compared with DOX-loaded reduction-sensitive PU micelles. The change of the size of this system under different conditions was further evaluated by DLS. DOX-loaded mPEG-PUSS-mPEG micelles in 50% fetal bovine serum (FBS) were evaluated the hemocompatibility. In addition, the self-assembly process of polymers mPEG-PUSS-mPEG in aqueous solution for micellar formation was also investigated by means of dissipative particle dynamics (DPD) simulations.AndCCK-8 assays revealed that the mPEG-PUSS-mPEG materials had low toxicity, but the DOX-loaded micelles showed a high cytotoxicity against HepG2 tumor cells. All results demonstrate that mPEG-PUSS-mPEG self-assembled micelles are a very promising for hydrophobic anticancer drugs delivery.

通过开环聚合（ROP）和加成反应相结合，开发了一系列两亲性聚合物mPEG-PUSS-mPEG，并开发了其自组装胶束用于疏水性抗癌药物的递送。水溶液中的聚合物临界胶束浓度（CMC）值约为2.8-5.5 mg / L。mice在胶束中的分配平衡常数（K _v）为1.52×10 ⁵至2.20×10 ⁵。通过动态光散射（DLS）确定的自组装空白和DOX加载的胶束的平均尺寸为160-180 nm。通过透射电子显微镜（TEM）和扫描电子显微镜（SEM），载有DOX的胶束的形态为球形。在不同的模拟条件下，研究了mPEG-PUSS-mPEG胶束中DOX和PTX的药物释放行为。我们发现，与加载DOX的还原敏感性PU胶束相比，氧化还原刺激显着促进了PTX的释放。DLS进一步评估了该系统在不同条件下的大小变化。评价了50％胎牛血清（FBS）中DOX加载的mPEG-PUSS-mPEG胶束的血液相容性。此外，还通过耗散粒子动力学（DPD）模拟研究了聚合物mPEG-PUSS-mPEG在胶束形成过程中的自组装过程.CCK-8分析表明mPEG-PUSS-mPEG材料具有较低的胶束形成能力。的毒性，但载有DOX的胶束对HepG2肿瘤细胞显示出高细胞毒性。